1887

Abstract

SUMMARY: Optimal yields of penicillinase were obtained by the continuous addition of penicillin to cultures of certain strains of during their logarithmic growth phase.

Lower yields of enzyme were obtained if the penicillin was added when growth had ceased or to partly grown cultures kept at rest and subsequently shaken.

Partial lysis of the bacteria was accompanied by an increased yield of enzyme, but complete lysis appeared to result in partial destruction.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-1-3-370
1947-09-01
2021-10-27
Loading full text...

Full text loading...

/deliver/fulltext/micro/1/3/mic-1-3-370.html?itemId=/content/journal/micro/10.1099/00221287-1-3-370&mimeType=html&fmt=ahah

References

  1. Abraham E. P., Chain E. 1940; An enzyme from bacteria able to destroy penicillin. Nature; Lond: 146837
    [Google Scholar]
  2. Benedict R. G., Schmidt W. H., Coghill R. D. 1945; Penicillin VII. Penicillinase. Arch. Biochem 8:377
    [Google Scholar]
  3. Duthie E. S. 1944; The production of penicillinase by organisms of the subtilis group. Brit. J. exp. Path 25:96
    [Google Scholar]
  4. Heatley N. G. 1944; A method for the assay of penicillin. Biochem. J 38:61
    [Google Scholar]
  5. Housewright R. D., Henry R. J. 1947a; Studies on penicillinase. I. J. biol. Chem 167:553
    [Google Scholar]
  6. Housewright R. D., Henry R. J. 1947b; Studies on penicillinase. II. J. biol. Chem 167:559
    [Google Scholar]
  7. Lawrence C. A. 1943; Sterility test for penicillin. Science 98:413
    [Google Scholar]
  8. Lawrence C. A. 1944; Action of clarase upon penicillin. Science 99:15
    [Google Scholar]
  9. Lawrence C. A. 1945a; Effect of enzyme preparations upon penicillin. I. J. Bact 49:47
    [Google Scholar]
  10. Lawtrence C. A. 1945b; Effect of enzyme preparations upon penicillin. II. J. Bact 49:57
    [Google Scholar]
  11. Lepage G. A., Morgan J. F., Campbell M. E. 1946; Production and purification of penicillinase. J. biol. Chem 166:465
    [Google Scholar]
  12. Mcadam I. W. J., Duguid J. P., Challinor S. W. 1944; Systemic administration of penicillin. Lancet ii:336
    [Google Scholar]
  13. Mcquarrie E. B., Liebmann A. J. 1944; Studies on penicillinase. Arch. Biochem 5:307
    [Google Scholar]
  14. Rogers H. J. 1945; The conditions controlling the production of hyaluronidase by micro-organisms grown in simplified media. Biochem. J 39:435
    [Google Scholar]
  15. Ungar J. 1944; Penicillinase from B. subtilis. Nature; Lond: 154236
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-1-3-370
Loading
/content/journal/micro/10.1099/00221287-1-3-370
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error