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Volume 7, Issue 9

Genome-wide analysis provides a deeper understanding of the population structure of the serotype Paratyphi B complex in Bangladesh Open Access

Abstract

The serotype Paratyphi B complex causes a wide range of diseases, from gastroenteritis to paratyphoid fever, depending on the biotypes Java and . The burden of Paratyphi B biotypes in Bangladesh is still unknown, as these are indistinguishable by serotyping. Here, we conducted the first whole-genome sequencing (WGS) study on 79 isolates serotyped as Paratyphi B that were collected from 10 nationwide enteric disease surveillance sites in Bangladesh. Placing these in a global genetic context revealed that these are biotype Java, and the addition of these genomes expanded the previously described PG4 clade containing Bangladeshi and UK isolates. Importantly, antimicrobial resistance (AMR) genes were scarce amongst Bangladeshi . Java isolates, somewhat surprisingly given the widespread availability of antibiotics without prescription. This genomic information provides important insights into the significance of . Paratyphi B biotypes in enteric disease and their implications for public health.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): enteric disease , Salmonella Paratyphi B , serotyping , surveillance and whole-genome sequencing
Funding
This study was supported by the:
  • National Institute for Health Research
    • Principle Award Recipient: GordonDougan
  • Bill and Melinda Gates Foundation (Award OPP1135223)
    • Principle Award Recipient: FirdausiQadri
  • Wellcome Trust (Award 206194)
    • Principle Award Recipient: FirdausiQadri
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2021-09-22
2024-04-26
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Genome-wide analysis provides a deeper understanding of the population structure of the Salmonella enterica serotype Paratyphi B complex in Bangladesh
M Gen 7, 000617 (2021); https://doi.org/10.1099/mgen.0.000617
/content/journal/mgen/10.1099/mgen.0.000617
/content/journal/mgen/10.1099/mgen.0.000617
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