1887

Abstract

Expression of a myriad of virulence factors and innate antibiotic resistance enables the opportunistic human pathogen to create intractable infections. Using a nematode model, we screened for novel inhibitors of this pathogen. Aqueous extracts of three plants, , and , were examined for their effects on killing of the nematode . The results were evaluated in toxin-based and infection-based assays using strains PAO1 and PA14. The tested plant extracts prevented mortality via gut infection in approximately 60 % of the worms and caused a 50–90 % reduction in death from toxin production. All extracts inhibited nematode death by without host toxicity, indicating their potential for further development as anti-infectives.

Keyword(s): QS, quorum sensing
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2008-07-01
2020-08-08
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