1887

Abstract

This study investigated the influence of urease-positive non- bacteria on the results of a urea breath test (UBT) to evaluate the diagnostic utility of a UBT using film-coated [C]urea tablets. The UBT was performed in 102 patients treated with a proton pump inhibitor and antibiotics for the eradication of . Urease-producing bacteria other than were isolated and identified from the oral cavity and stomach. In 4/102 patients, the UBT gave false-positive results. These false-positive results were found to be caused by the presence of urease-positive bacteria in the oral cavity and stomach. Five bacterial species with urease activity (, , , and ) were subsequently isolated from the oral cavity and/or stomach. As there was no correlation between the urease activity of urease-positive non- bacteria and the UBT value, and all of the patients with a false-positive UBT result were suffering from atrophic gastritis, it is possible that the false-positive results in the UBT were a result of colonization of urease-positive bacteria and gastric hypochlorhydric conditions. Thus, for the diagnosis of infection using a UBT, the influence of stomach bacteria must be considered when interpreting the results.

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2008-07-01
2019-10-18
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