1887

Abstract

Interleukin-1 receptor-associated kinase (IRAK)-4 deficiency is a rare primary immunodeficiency disorder characterized by severe, invasive infections with . Using the PFGE technique a genetic linkage was found between two serotype 14 isolates causing arthritis and meningitis at 3 and 5½ years of age, respectively, in a boy with IRAK-4 deficiency. This finding suggested that patients with IRAK-4 deficiency may harbour persistent strains of pneumococci. Alternatively, reinfection with strains from close contacts of the patient might cause recurrent invasive disease. It is proposed that eradication of pneumococci from the nasopharynx, and immunization of household contacts may prevent recurrent infection in IRAK-4-deficient patients.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.47046-0
2007-06-01
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/jmm/56/6/863.html?itemId=/content/journal/jmm/10.1099/jmm.0.47046-0&mimeType=html&fmt=ahah

References

  1. Brito D. A., Ramirez M. H., de Lencastre H. 2003; Serotyping Streptococcus pneumoniae by multiplex PCR. J Clin Microbiol 41:2378–2384 [CrossRef]
    [Google Scholar]
  2. Dobay O., Rozgonyi F., Amyes S. G. B. 2005a; Molecular characterization of Hungarian macrolide resistant Streptococcus pneumoniae isolates, including 3 highly resistant strains with mef gene. Int J Antimicrob Agents 25:488–495 [CrossRef]
    [Google Scholar]
  3. Dobay O., Rozgonyi F., Hajdú E., Nagy E., Knausz M., Amyes S. G. B. 2005b; The relationship between serotypes and PFGE genotypes in isolates of Streptococcus pneumoniae from Hungary. Clin Microbiol Infect 11:673–676 [CrossRef]
    [Google Scholar]
  4. Hall L. M., Whiley C., Duke R. A. B., George R. C., Efstratiou A. 1996; Genetic relatedness within and between serotypes of Streptococcus pneumoniae from the United Kingdom: analysis of multilocus enzyme electrophoresis, pulsed-field gel electrophoresis, and antimicrobial resistance patterns. J Clin Microbiol 34:853–859
    [Google Scholar]
  5. King M. D., Whitney C. G., Parekh F., Farley M. M. 2003; Recurrent invasive pneumococcal disease: a population-based assessment. Clin Infect Dis 37:1029–1036 [CrossRef]
    [Google Scholar]
  6. Ku C. L., Picard C., Erdős M., Jeurissen A., Bustamante J., Puel A., von Bernuth H., Filipe-Santos O., Chang H. H. other authors 2007; IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease. J Med Genet 44:16–23
    [Google Scholar]
  7. Maródi L., Káposzta R., Nemes É. 2000; Survival of group B Streptococcus type III in mononuclear phagocytes: differential regulation of bacterial killing in cord macrophages by human recombinant gamma interferon and granulocyte-macrophage colony-stimulating factor. Infect Immun 68:2167–2170 [CrossRef]
    [Google Scholar]
  8. Nagai K., Shibasaki Y., Hasegawa K., Davies T. A., Jacobs M. R., Ubukata K., Appelbaum P. C. 2001; Evaluation of PCR primers to screen for Streptococcus pneumoniae isolates and β -lactam resistance, and to detect common macrolide resistance determinants. J Antimicrob Chemother 48:915–918 [CrossRef]
    [Google Scholar]
  9. Picard C., Puel A., Bonnet M., Ku C. L., Bustamante J., Yang K., Soudais C., Dupuis S., Feinberg J. other authors 2003; Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 299:2076–2079 [CrossRef]
    [Google Scholar]
  10. Yang K., Puel A., Zhang S., Eidenschenk C., Ku C. L., Casrouge A., Picard C., von Bernuth H., Senechal B. other authors 2005; Human TLR-7, -8, and -9-mediated induction of IFN- α / β and - λ is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity 23:465–478 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.47046-0
Loading
/content/journal/jmm/10.1099/jmm.0.47046-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error