1887

Abstract

Resveratrol (3,5,4-trihydroxy--stilbene) is a phytoalexin compound with anti-inflammatory and antioxidant activities. The effect of resveratrol on swarming and virulence factor expression of , an important pathogen infecting the urinary tract, was determined on swarming agar plates with and without the compound. Bacteria harvested at different times were assayed for cell length and the production of flagella, haemolysin and urease. Resveratrol inhibited swarming and virulence factor expression in a dose-dependent manner. Resveratrol significantly inhibited swarming at 15 μg ml, and completely inhibited swarming at 60 μg ml. Inhibition of swarming and virulence factor expression was mediated through RsbA, a His-containing phosphotransmitter of the bacterial two-component signalling system possibly involved in quorum sensing. Complementation of an -defective mutant with the gene restored its responsiveness to resveratrol. The compound also inhibited the ability of to invade human urothelial cells. These findings suggest that resveratrol has potential to be developed as an antimicrobial agent against infection.

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2006-10-01
2019-10-19
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