1887

Abstract

To investigate the possibility of an interaction between two ubiquitous human pathogens, and Epstein–Barr virus (EBV), the effect of monochloramine (NHCl), locally produced by infection, on gastric epithelium latently infected with EBV was examined, by assessing the induction of EBV lytic infection. AGS cells harbouring latently infected EBV were used as the indicator of lytic change caused by NHCl treatment. Lytic infection, determined by morphological change and EA-D antigen expression, occurred immediately after treatment with -synthesized NHCl. Analysis of EBV infection in human gastric tissue revealed that out of 48 -positive patients, 24 were positive for EBER-1, and 18 and 13 were positive for EBNA1 and LMP-1 antigen, respectively. The results suggest that -associated NHCl induces EBV lytic conversion in gastric epithelium latently infected with EBV.

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2006-07-01
2019-10-17
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