1887

Abstract

Enterohaemorrhagic (EHEC) and enteropathogenic (EPEC) are important diarrhoeagenic pathogens; infection is dependent on translocation of a number of type III effector proteins. Until recently all the known effectors were encoded on the LEE pathogenicity island, which also encodes the adhesin intimin and the type III secretion apparatus. Recently, a novel non-LEE effector protein, EspI/NleA, which is required for full virulence and is encoded on a prophage, was identified. The aim of this study was to determine the distribution of among clinical EHEC and EPEC isolates. was detected in 86 % and 53 % of LEE EHEC and EPEC strains, respectively. Moreover, the gene was more commonly found in patients suffering from a more severe disease.

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2004-11-01
2019-11-22
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