1887

Abstract

Although the incidence of gastric cancer in the Dominican Republic is not high, the disease remains a significant health problem. We first conducted a detailed analysis of status in the Dominican Republic. In total, 158 patients (103 females and 55 males; mean age 47.1±16.2 years) were recruited. The status of infection was determined based on four tests: rapid urease test, culture test, histological test and immunohistochemistry. The status of and genotypes in was examined using PCR and gene sequencing. The overall prevalence of infection was 58.9 %. No relationship was found between the infection rate and the age range of 17–91 years. Even in the youngest group (patients aged <29 years), the infection rate was 62.5 %. Peptic ulcer was found in 23 patients and gastric cancer was found in one patient. The infection rate in patients with peptic ulcer was significantly higher than that in patients with gastritis (82.6 versus 54.5 %, <0.01). The -positive/ s1m1 genotype was the most prevalent (43/64, 67.2 %). Compared with -negative patients, -positive patients showed more severe gastritis. Furthermore, the presence of was related to the presence of more severe gastritis. All CagA-positive strains had Western-type CagA. In conclusion, we found that infection is a risk factor for peptic ulcer in the Dominican Republic. Patients with -positive could be at higher risk for severe inflammation and atrophy.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.075275-0
2014-09-01
2019-11-17
Loading full text...

Full text loading...

/deliver/fulltext/jmm/63/9/1189.html?itemId=/content/journal/jmm/10.1099/jmm.0.075275-0&mimeType=html&fmt=ahah

References

  1. Aoki K. , Kihaile P. E. , Castro M. , Disla M. , Nyambo T. B. , Misumi J. . ( 2004; ). Seroprevalences of Helicobacter pylori infection and chronic zatrophic gastritis in the United Republic of Tanzania and the Dominican Republic. . Environ Health Prev Med 9:, 170–175. [CrossRef] [PubMed]
    [Google Scholar]
  2. Aoki K. , Kihaile P. E. , Wenyuan Z. , Xianghang Z. , Castro M. , Disla M. , Nyambo T. B. , Misumi J. . ( 2005; ). Comparison of prevalence of chronic atrophic gastritis in Japan, China, Tanzania, and the Dominican Republic. . Ann Epidemiol 15:, 598–606. [CrossRef] [PubMed]
    [Google Scholar]
  3. Argent R. H. , Kidd M. , Owen R. J. , Thomas R. J. , Limb M. C. , Atherton J. C. . ( 2004; ). Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori . . Gastroenterology 127:, 514–523. [CrossRef] [PubMed]
    [Google Scholar]
  4. Asaka M. , Kimura T. , Kudo M. , Takeda H. , Mitani S. , Miyazaki T. , Miki K. , Graham D. Y. . ( 1992; ). Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. . Gastroenterology 102:, 760–766.[PubMed]
    [Google Scholar]
  5. Asaka M. , Kato M. , Takahashi S. , Fukuda Y. , Sugiyama T. , Ota H. , Uemura N. , Murakami K. , Satoh K. , Sugano K. . Japanese Society for Helicobacter Research ( 2010; ). Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition. . Helicobacter 15:, 1–20. [CrossRef] [PubMed]
    [Google Scholar]
  6. Atherton J. C. , Cao P. , Peek R. M. Jr , Tummuru M. K. , Blaser M. J. , Cover T. L. . ( 1995; ). Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. . J Biol Chem 270:, 17771–17777. [CrossRef] [PubMed]
    [Google Scholar]
  7. Azevedo N. F. , Huntington J. , Goodman K. J. . ( 2009; ). The epidemiology of Helicobacter pylori and public health implications. . Helicobacter 14: (Suppl 1), 1–7. [CrossRef] [PubMed]
    [Google Scholar]
  8. Azuma T. , Yamakawa A. , Yamazaki S. , Fukuta K. , Ohtani M. , Ito Y. , Dojo M. , Yamazaki Y. , Kuriyama M. . ( 2002; ). Correlation between variation of the 3′ region of the cagA gene in Helicobacter pylori and disease outcome in Japan. . J Infect Dis 186:, 1621–1630. [CrossRef] [PubMed]
    [Google Scholar]
  9. Bornschein J. , Selgrad M. , Wex T. , Kuester D. , Malfertheiner P. . ( 2012; ). Serological assessment of gastric mucosal atrophy in gastric cancer. . BMC Gastroenterol 12:, 10. [CrossRef] [PubMed]
    [Google Scholar]
  10. Brenner H. , Rothenbacher D. , Weck M. N. . ( 2007; ). Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value. . Int J Cancer 121:, 2782–2786. [CrossRef] [PubMed]
    [Google Scholar]
  11. Burucoa C. , Delchier J. C. , Courillon-Mallet A. , de Korwin J. D. , Mégraud F. , Zerbib F. , Raymond J. , Fauchère J. L. . ( 2013; ). Comparative evaluation of 29 commercial Helicobacter pylori serological kits. . Helicobacter 18:, 169–179. [CrossRef] [PubMed]
    [Google Scholar]
  12. Calvet X. , Ramírez Lázaro M. J. , Lehours P. , Mégraud F. . ( 2013; ). Diagnosis and epidemiology of Helicobacter pylori infection. . Helicobacter 18: (Suppl 1), 5–11. [CrossRef] [PubMed]
    [Google Scholar]
  13. Covacci A. , Censini S. , Bugnoli M. , Petracca R. , Burroni D. , Macchia G. , Massone A. , Papini E. , Xiang Z. . & other authors ( 1993; ). Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. . Proc Natl Acad Sci U S A 90:, 5791–5795. [CrossRef] [PubMed]
    [Google Scholar]
  14. Cover T. L. , Blaser M. J. . ( 1992; ). Purification and characterization of the vacuolating toxin from Helicobacter pylori . . J Biol Chem 267:, 10570–10575.[PubMed]
    [Google Scholar]
  15. Dattoli V. C. , Veiga R. V. , da Cunha S. S. , Pontes-de-Carvalho L. C. , Barreto M. L. , Alcântara-Neves N. M. . ( 2010; ). Seroprevalence and potential risk factors for Helicobacter pylori infection in Brazilian children. . Helicobacter 15:, 273–278. [CrossRef] [PubMed]
    [Google Scholar]
  16. Dixon M. F. , Genta R. M. , Yardley J. H. , Correa P. . ( 1996; ). Classification and grading of gastritis: the updated Sydney System. . Am J Surg Pathol 20:, 1161–1181. [CrossRef] [PubMed]
    [Google Scholar]
  17. Ferlay J. , Shin H. R. , Bray F. , Forman D. , Mathers C. , Parkin D. M. . ( 2010; ). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. . Int J Cancer 127:, 2893–2917. [CrossRef] [PubMed]
    [Google Scholar]
  18. Goh K. L. , Chan W. K. , Shiota S. , Yamaoka Y. . ( 2011; ). Epidemiology of Helicobacter pylori infection and public health implications. . Helicobacter 16: (Suppl 1), 1–9. [CrossRef] [PubMed]
    [Google Scholar]
  19. Hisada M. , Lee M. G. , Hanchard B. , Owens M. , Song Q. , van Doorn L. J. , Cutler A. F. , Gold B. D. . ( 2001; ). Characteristics of Helicobacter pylori infection in Jamaican adults with gastrointestinal symptoms. . J Clin Microbiol 39:, 212–216. [CrossRef] [PubMed]
    [Google Scholar]
  20. Huang J. Q. , Sridhar S. , Hunt R. H. . ( 2002; ). Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis. . Lancet 359:, 14–22. [CrossRef] [PubMed]
    [Google Scholar]
  21. Kodama M. , Murakami K. , Okimoto T. , Abe T. , Nakagawa Y. , Mizukami K. , Uchida M. , Inoue K. , Fujioka T. . ( 2012a; ). Helicobacter pylori eradication improves gastric atrophy and intestinal metaplasia in long-term observation. . Digestion 85:, 126–130. [CrossRef] [PubMed]
    [Google Scholar]
  22. Kodama M. , Murakami K. , Okimoto T. , Sato R. , Uchida M. , Abe T. , Shiota S. , Nakagawa Y. , Mizukami K. , Fujioka T. . ( 2012b; ). Ten-year prospective follow-up of histological changes at five points on the gastric mucosa as recommended by the updated Sydney system after Helicobacter pylori eradication. . J Gastroenterol 47:, 394–403. [CrossRef] [PubMed]
    [Google Scholar]
  23. Leja M. , Cine E. , Rudzite D. , Vilkoite I. , Huttunen T. , Daugule I. , Rumba-Rozenfelde I. , Pimanov S. , Liepniece-Karele I. . & other authors ( 2012; ). Prevalence of Helicobacter pylori infection and atrophic gastritis in Latvia. . Eur J Gastroenterol Hepatol 24:, 1410–1417. [CrossRef] [PubMed]
    [Google Scholar]
  24. Leung W. K. , Wu M. S. , Kakugawa Y. , Kim J. J. , Yeoh K. G. , Goh K. L. , Wu K. C. , Wu D. C. , Sollano J. . & other authors ( 2008; ). Screening for gastric cancer in Asia: current evidence and practice. . Lancet Oncol 9:, 279–287. [CrossRef] [PubMed]
    [Google Scholar]
  25. Malaty H. M. . ( 2007; ). Epidemiology of Helicobacter pylori infection. . Best Pract Res Clin Gastroenterol 21:, 205–214. [CrossRef] [PubMed]
    [Google Scholar]
  26. Malfertheiner P. , Megraud F. , O’Morain C. A. , Atherton J. , Axon A. T. , Bazzoli F. , Gensini G. F. , Gisbert J. P. , Graham D. Y. . & other authors ( 2012; ). Management of Helicobacter pylori infection – the Maastricht IV/Florence Consensus Report. . Gut 61:, 646–664. [CrossRef] [PubMed]
    [Google Scholar]
  27. Matsuda M. , Shiota S. , Matsunari O. , Watada M. , Murakami K. , Fujioka T. , Yamaoka Y. . ( 2011; ). Prevalence of two homologous genes encoding glycosyltransferases of Helicobacter pylori in the United States and Japan. . J Gastroenterol Hepatol 26:, 1451–1456.[PubMed] [CrossRef]
    [Google Scholar]
  28. Matsunari O. , Shiota S. , Suzuki R. , Watada M. , Kinjo N. , Murakami K. , Fujioka T. , Kinjo F. , Yamaoka Y. . ( 2012; ). Association between Helicobacter pylori virulence factors and gastroduodenal diseases in Okinawa, Japan. . J Clin Microbiol 50:, 876–883. [CrossRef] [PubMed]
    [Google Scholar]
  29. Mégraud F. . ( 1997; ). A growing demand for Helicobacter pylori culture in the near future?. Ital J Gastroenterol Hepatol 29:, 574–576.[PubMed]
    [Google Scholar]
  30. Mégraud F. , Lehours P. . ( 2007; ). Helicobacter pylori detection and antimicrobial susceptibility testing. . Clin Microbiol Rev 20:, 280–322. [CrossRef] [PubMed]
    [Google Scholar]
  31. Miki K. . ( 2011; ). Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels – “ABC method”. . Proc Jpn Acad, Ser B, Phys Biol Sci 87:, 405–414. [CrossRef] [PubMed]
    [Google Scholar]
  32. Papatheodoridis G. V. , Sougioultzis S. , Archimandritis A. J. . ( 2006; ). Effects of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on peptic ulcer disease: a systematic review. . Clin Gastroenterol Hepatol 4:, 130–142. [CrossRef] [PubMed]
    [Google Scholar]
  33. Parsonnet J. , Friedman G. D. , Vandersteen D. P. , Chang Y. , Vogelman J. H. , Orentreich N. , Sibley R. K. . ( 1991; ). Helicobacter pylori infection and the risk of gastric carcinoma. . N Engl J Med 325:, 1127–1131. [CrossRef] [PubMed]
    [Google Scholar]
  34. Peek R. M. Jr , Blaser M. J. . ( 2002; ). Helicobacter pylori and gastrointestinal tract adenocarcinomas. . Nat Rev Cancer 2:, 28–37. [CrossRef] [PubMed]
    [Google Scholar]
  35. Porras C. , Nodora J. , Sexton R. , Ferreccio C. , Jimenez S. , Dominguez R. L. , Cook P. , Anderson G. , Morgan D. R. . & other authors ( 2013; ). Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701). . Cancer Causes Control 24:, 209–215. [CrossRef] [PubMed]
    [Google Scholar]
  36. Rugge M. , Genta R. M. . OLGA Group ( 2005; ). Staging gastritis: an international proposal. . Gastroenterology 129:, 1807–1808. [CrossRef] [PubMed]
    [Google Scholar]
  37. Rugge M. , Meggio A. , Pennelli G. , Piscioli F. , Giacomelli L. , De Pretis G. , Graham D. Y. . ( 2007; ). Gastritis staging in clinical practice: the OLGA staging system. . Gut 56:, 631–636. [CrossRef] [PubMed]
    [Google Scholar]
  38. Satoh K. , Osawa H. , Yoshizawa M. , Nakano H. , Hirasawa T. , Kihira K. , Sugano K. . ( 2008; ). Assessment of atrophic gastritis using the OLGA system. . Helicobacter 13:, 225–229. [CrossRef] [PubMed]
    [Google Scholar]
  39. Shak J. R. , Sodikoff J. B. , Speckman R. A. , Rollin F. G. , Chery M. P. , Cole C. R. , Suchdev P. S. . ( 2011; ). Anemia and Helicobacter pylori seroreactivity in a rural Haitian population. . Am J Trop Med Hyg 85:, 913–918. [CrossRef] [PubMed]
    [Google Scholar]
  40. Shiota S. , Mahachai V. , Vilaichone R. K. , Ratanachu-ek T. , Tshering L. , Uchida T. , Matsunari O. , Yamaoka Y. . ( 2013; ). Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer. . J Med Microbiol 62:, 1571–1578. [CrossRef] [PubMed]
    [Google Scholar]
  41. Strebel K. , Rolle-Kampczyk U. , Richter M. , Kindler A. , Richter T. , Schlink U. . ( 2010; ). A rigorous small area modelling-study for the Helicobacter pylori epidemiology. . Sci Total Environ 408:, 3931–3942. [CrossRef] [PubMed]
    [Google Scholar]
  42. Suerbaum S. , Michetti P. . ( 2002; ). Helicobacter pylori infection. . N Engl J Med 347:, 1175–1186. [CrossRef] [PubMed]
    [Google Scholar]
  43. Sugimoto M. , Yamaoka Y. . ( 2009; ). The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations. . Clin Microbiol Infect 15:, 835–842. [CrossRef] [PubMed]
    [Google Scholar]
  44. Sugimoto M. , Zali M. R. , Yamaoka Y. . ( 2009; ). The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East. . Eur J Clin Microbiol Infect Dis 28:, 1227–1236. [CrossRef] [PubMed]
    [Google Scholar]
  45. Suzuki R. , Shiota S. , Yamaoka Y. . ( 2012; ). Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori . . Infect Genet Evol 12:, 203–213. [CrossRef] [PubMed]
    [Google Scholar]
  46. Tonkic A. , Tonkic M. , Lehours P. , Mégraud F. . ( 2012; ). Epidemiology and diagnosis of Helicobacter pylori infection. . Helicobacter 17: (Suppl 1), 1–8. [CrossRef] [PubMed]
    [Google Scholar]
  47. Torres L. E. , Melián K. , Moreno A. , Alonso J. , Sabatier C. A. , Hernández M. , Bermúdez L. , Rodríguez B. L. . ( 2009; ). Prevalence of vacA, cagA and babA2 genes in Cuban Helicobacter pylori isolates. . World J Gastroenterol 15:, 204–210. [CrossRef] [PubMed]
    [Google Scholar]
  48. Torres L. E. , González L. , Melián K. , Alonso J. , Moreno A. , Hernández M. , Reyes O. , Bermúdez L. , Campos J. . & other authors ( 2012; ). EPIYA motif patterns among Cuban Helicobacter pylori CagA positive strains. . Biomedica 32:, 23–31.[PubMed]
    [Google Scholar]
  49. Tummuru M. K. , Cover T. L. , Blaser M. J. . ( 1993; ). Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. . Infect Immun 61:, 1799–1809.[PubMed]
    [Google Scholar]
  50. Uchida T. , Kanada R. , Tsukamoto Y. , Hijiya N. , Matsuura K. , Yano S. , Yokoyama S. , Kishida T. , Kodama M. . & other authors ( 2007; ). Immunohistochemical diagnosis of the cagA-gene genotype of Helicobacter pylori with anti-East Asian CagA-specific antibody. . Cancer Sci 98:, 521–528. [CrossRef] [PubMed]
    [Google Scholar]
  51. Uemura N. , Okamoto S. , Yamamoto S. , Matsumura N. , Yamaguchi S. , Yamakido M. , Taniyama K. , Sasaki N. , Schlemper R. J. . ( 2001; ). Helicobacter pylori infection and the development of gastric cancer. . N Engl J Med 345:, 784–789. [CrossRef] [PubMed]
    [Google Scholar]
  52. van Doorn L. J. , Figueiredo C. , Sanna R. , Plaisier A. , Schneeberger P. , de Boer W. , Quint W. . ( 1998; ). Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori . . Gastroenterology 115:, 58–66. [CrossRef] [PubMed]
    [Google Scholar]
  53. Vilaichone R. K. , Mahachai V. , Tumwasorn S. , Wu J. Y. , Graham D. Y. , Yamaoka Y. . ( 2004; ). Molecular epidemiology and outcome of Helicobacter pylori infection in Thailand: a cultural cross roads. . Helicobacter 9:, 453–459. [CrossRef] [PubMed]
    [Google Scholar]
  54. Vilaichone R. K. , Mahachai V. , Shiota S. , Uchida T. , Ratanachu-ek T. , Tshering L. , Tung N. L. , Fujioka T. , Moriyama M. , Yamaoka Y. . ( 2013; ). Extremely high prevalence of Helicobacter pylori infection in Bhutan. . World J Gastroenterol 19:, 2806–2810. [CrossRef] [PubMed]
    [Google Scholar]
  55. Xia Y. , Yamaoka Y. , Zhu Q. , Matha I. , Gao X. . ( 2009; ). A comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori. . PLoS ONE 4:, e7736. [CrossRef] [PubMed]
    [Google Scholar]
  56. Yamaoka Y. . ( 2010; ). Mechanisms of disease: Helicobacter pylori virulence factors. . Nat Rev Gastroenterol Hepatol 7:, 629–641.[PubMed]
    [Google Scholar]
  57. Yamaoka Y. , Kodama T. , Kashima K. , Graham D. Y. , Sepulveda A. R. . ( 1998a; ). Variants of the 3′ region of the cagA gene in Helicobacter pylori isolates from patients with different H. pylori-associated diseases. . J Clin Microbiol 36:, 2258–2263.[PubMed]
    [Google Scholar]
  58. Yamaoka Y. , Kodama T. , Kita M. , Imanishi J. , Kashima K. , Graham D. Y. . ( 1998b; ). Relationship of vacA genotypes of Helicobacter pylori to cagA status, cytotoxin production, and clinical outcome. . Helicobacter 3:, 241–253. [CrossRef] [PubMed]
    [Google Scholar]
  59. Yamaoka Y. , El-Zimaity H. M. , Gutierrez O. , Figura N. , Kim J. K. , Kodama T. , Kashima K. , Graham D. Y. . ( 1999a; ). Relationship between the cagA 3′ repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH. . Gastroenterology 117:, 342–349. [CrossRef] [PubMed]
    [Google Scholar]
  60. Yamaoka Y. , Kodama T. , Gutierrez O. , Kim J. G. , Kashima K. , Graham D. Y. . ( 1999b; ). Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries. . J Clin Microbiol 37:, 2274–2279.[PubMed]
    [Google Scholar]
  61. Yamaoka Y. , Osato M. S. , Sepulveda A. R. , Gutierrez O. , Figura N. , Kim J. G. , Kodama T. , Kashima K. , Graham D. Y. . ( 2000; ). Molecular epidemiology of Helicobacter pylori: separation of H. pylori from East Asian and non-Asian countries. . Epidemiol Infect 124:, 91–96. [CrossRef] [PubMed]
    [Google Scholar]
  62. Yamaoka Y. , Kikuchi S. , el-Zimaity H. M. , Gutierrez O. , Osato M. S. , Graham D. Y. . ( 2002; ). Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production. . Gastroenterology 123:, 414–424. [CrossRef] [PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.075275-0
Loading
/content/journal/jmm/10.1099/jmm.0.075275-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error