1887

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Volume 63, Issue 1

Analysis of the microbial ecology between and the gastric microbiota of Mongolian gerbils Free

Abstract

Animal models are essential for analysis of -related diseases. Mongolian gerbils are used frequently to study -induced gastritis and its consequences. The presence of some gastric microbiota with a suppressive effect on suggests inhibitory gastric bacteria against infection. The aim of the present study was to analyse the microbial ecology between and the gastric microbiota of Mongolian gerbils. Gastric mucosa samples of -negative and -positive gerbils were orally inoculated to five (Group 1) and six (Group 2) gerbils, respectively, and the gerbils were challenged with infection. The colonization rate (40 %) of in Group 1 gerbils was lower than the rate (67 %) in Group 2 gerbils. Culture filtrate of the gastric mucosa samples of Group 1 gerbils inhibited the growth of . Three lactobacilli species, , and , were isolated by anaerobic culture from the gerbils in Groups 1 and 2, and identified by genomic sequencing. It was demonstrated that the three different strains of lactobacilli exhibited an inhibitory effect on the growth of . The results suggested that lactobacilli are the dominant gastric microbiota of Mongolian gerbils and the three lactobacilli isolated from the gastric mucosa samples with an inhibitory effect on might have an anti-infective effect against .

  • Received:
  • Accepted:
  • Published Online:
© 2014 SGM
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2014-01-01
2024-04-26
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Analysis of the microbial ecology between Helicobacter pylori and the gastric microbiota of Mongolian gerbils
J. Med. Microbiol. 63, 129 (2014); https://doi.org/10.1099/jmm.0.061135-0
/content/journal/jmm/10.1099/jmm.0.061135-0
/content/journal/jmm/10.1099/jmm.0.061135-0
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