1887

Abstract

The objective of this study was to investigate the susceptibility of hospital-associated (HA) and community-associated (CA) and isolated from patients with intra-abdominal infections (IAIs) in China. From 2002 to 2011, the minimum inhibitory concentrations (MICs) of 12 antibiotics against 3074 and 1025 from 23 centres located in 16 cities were determined by the broth microdilution method. During the 10 year study period, ertapenem, imipenem, amikacin and piperacillin-tazobactam retained high and stable activity against and isolates regardless of whether their source was HA or CA and regardless of their extended-spectrum beta-lactamase (ESBL) production. However, the susceptibility of to cephalosporins and ampicillin-sulbactam decreased dramatically during the 10 years, especially for the CA isolates. Fluoroquinolones showed low activity against . During the whole study period, the ESBL rates for isolates from IAIs increased from 36.1 % in 2002–2003 to 68.1 % in 2010–2011 (<0.001). Correspondingly, the ESBL rates in HA isolates increased from 52.2 % in 2002–2003 to 70.0 % in 2010–2011 ( = 0.001), and in CA isolates from 19.1 % in 2002–2003 to 61.6 % in 2010–2011 (<0.001). The ESBL-positive rate in remained between 30.1 and 39.3 % of the total isolates with no significant change during the 10 years. In conclusion, carbapenems retained the highest susceptibility rates against HA and CA and . High prevalence of ESBL in HA and fast-growing resistance in CA severely limit the empirical use of the third- and fourth-generation cephalosporins in the therapy of IAIs.

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2013-09-01
2020-01-21
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