1887

Abstract

High levels of pro-inflammatory cytokines are implicated in the severity of invasive meningococcal disease (IMD) and viral meningitis (VM). This study compared single-nucleotide polymorphisms (SNPs) in pro- and anti-inflammatory cytokine genes among patients with VM or IMD. Patient DNA samples were prepared by the National Meningitis Reference Laboratory in Athens:  = 98 for IMD and  = 53 for VM. The results for both patient groups were compared with data published for healthy Greek control data. Real-time PCR was used to assess the interleukin (IL) gene SNPs G−174C, C−511T, T+2018C, G−1082A and A−251T and the tumour necrosis factor α (TNF-α) SNP G−308A. Differences were compared by Fisher’s exact test. The genotype for high IL-6 responses was predominant among IMD (51 %,  = 0.0008) and VM (74.5 %, <0.0001) patients compared with the controls (31 %). The genotype associated with high TNF-α responses was 5 % among controls and lower for IMD (1.1 %,  = 0.0014) and VM (0 %,  = 0.052). There was no difference for IL-8 SNPs between controls and IMD ( = 0.162), but the difference was significant for VM ( = 0.0025). IL-6 ( = 0.024) and IL-8 ( = 0.00004) SNPs differed between IMD and VM. Reports on associations between IL-8 SNPs and cytokine responses differ. Because of its role in neutrophil attraction, differences in frequencies of the IL-8 SNP for IMD and VM require further investigation.

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2013-05-01
2019-10-18
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