1887

Abstract

Translocated effector protein, SopE, leads to actin cytoskeletal rearrangements and membrane ruffling. Only a subset of serotypes possess , with the majority of -carrying serotype Typhimurium associated with epidemics. Using real-time PCR and sequencing, was investigated in the ten most prevalent serotypes of in England and Wales in 2001. was identified in . Typhimurium definitive phage types 29, 44, 49, 204b and 204c, all of which either have been involved in major epidemics or are precursors of epidemic strains. The presence of varied in the remaining nine serotypes, but was more common in the top four (Enteritidis, Virchow, Hadar and Newport). Nucleotide changes were detected throughout and may result in altered specificity for certain signal transduction pathways. Since acquisition of may play a key role in emergence of epidemic strains, detection of could aid identification of those strains with the potential for epidemic spread.

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2004-06-01
2019-11-13
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vol. , part 6, pp. 539 - 543

Amino acid sequence alignment of PCR products of . Data were translated from the 642 bp nucleotide sequences of PCR products. Typhimurium (taken from accession no. AF043239), Enteritidis (AY167929), Infantis (AY167931), Typhi (AF153829), Virchow (V1) (AY168875), Virchow (V2) (AY168876), Java (AY167930), Newport (AY168873) and Hadar (AY168874). [PDF](62 KB)



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