1887

Abstract

The occurrence of multidrug-resistant or meticillin-resistant (MRSA) has become an important issue in clinics. This study evaluated a combinatorial treatment approach by using the well-documented antibacterial protein apo-bovine lactoferrin (apo-bLf) or its hydrolysate and specific probiotic supernatants for controlling MRSA infection. Clinical MRSA strains were isolated from different patient specimens. Apo-bLf-hydrolysate possessed stronger anti-MRSA activity than complete bLf in that it inhibited the growth of most MRSA strains tested . Otherwise, the supernatants produced by (ATCC 11739), subsp. (ATCC 15707) and subsp. (BCRC 17394) inhibited the growth of various MRSA strains. Further, or subsp. supernatant plus apo-bLf or bLf-hydrolysate led to partially synergistic to synergistic growth-inhibitory activity against MRSA strains. However, and not subsp. or subsp. was observed to resist the antibacterial activity of both apo-Lf and bLf-hydrolysate. Therefore, it is suggested that could be the best candidate to be used with apo-bLf or bLf-hydrolysate as a live supplement against MRSA infections.

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2013-12-01
2020-07-12
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