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Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 62, Issue 12

Synergistic antibacterial efficacies of the combination of bovine lactoferrin or its hydrolysate with probiotic secretion in curbing the growth of meticillin-resistant No Access

Abstract

The occurrence of multidrug-resistant or meticillin-resistant (MRSA) has become an important issue in clinics. This study evaluated a combinatorial treatment approach by using the well-documented antibacterial protein apo-bovine lactoferrin (apo-bLf) or its hydrolysate and specific probiotic supernatants for controlling MRSA infection. Clinical MRSA strains were isolated from different patient specimens. Apo-bLf-hydrolysate possessed stronger anti-MRSA activity than complete bLf in that it inhibited the growth of most MRSA strains tested . Otherwise, the supernatants produced by (ATCC 11739), subsp. (ATCC 15707) and subsp. (BCRC 17394) inhibited the growth of various MRSA strains. Further, or subsp. supernatant plus apo-bLf or bLf-hydrolysate led to partially synergistic to synergistic growth-inhibitory activity against MRSA strains. However, and not subsp. or subsp. was observed to resist the antibacterial activity of both apo-Lf and bLf-hydrolysate. Therefore, it is suggested that could be the best candidate to be used with apo-bLf or bLf-hydrolysate as a live supplement against MRSA infections.

  • Received:
  • Accepted:
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© 2013 SGM
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/content/journal/jmm/10.1099/jmm.0.052639-0
2013-12-01
2025-01-23
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/content/journal/jmm/10.1099/jmm.0.052639-0
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Synergistic antibacterial efficacies of the combination of bovine lactoferrin or its hydrolysate with probiotic secretion in curbing the growth of meticillin-resistant Staphylococcus aureus
J. Med. Microbiol. 62, 1845 (2013); https://doi.org/10.1099/jmm.0.052639-0
/content/journal/jmm/10.1099/jmm.0.052639-0
/content/journal/jmm/10.1099/jmm.0.052639-0
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