1887

Abstract

We report a rare case of infection by two different types of strains in a child who received only one dose of the serotype b (Hib) conjugate vaccine (DTwP+Hib). The strains were recovered from blood and cerebrospinal fluid (CSF) and were phenotypically identified as Hib and non-typable , respectively, after serological tests. The two strains were characterized by PCR capsular typing, multilocus sequence typing and PFGE. Our results suggest that the infection was caused by the bloodstream invasion by a single Hib strain, followed by the diffusion of the bacteria across the blood–brain barrier and into the CSF. The strain recovered from the CSF, however, was identified as a capsule-deficient type mutant (b) strain. Despite the high efficacy of the Hib conjugate vaccine, the increase in the numbers of strains able to escape the immune system of the vaccinated population advocates continued surveillance.

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2013-04-01
2019-10-19
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