1887

Abstract

During 2000, the UK witnessed a sudden increase in severe infections and related deaths in injecting drug users (IDUs), sparking off a UK-wide investigation. A worrying upward trend in severe group A streptococcal (GAS) infections has recently been observed in IDUs based upon isolate referrals to the PHLS Respiratory and Systemic Infection Laboratory. Most cases were young male adults who presented with skin sepsis and bacteraemia. Serotyping revealed a diverse range of M types, with higher types predominating in some geographical areas. The data suggest that GAS invasive soft-tissue infections may present in an epidemic fashion among IDUs in the absence of a common source.

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2003-06-01
2024-12-13
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References

  1. Böhlen L. M, Mühlemann K, Dubuis O, Aebi C, Täuber M. G. 2000; Outbreak among drug users caused by a clonal strain of group A streptococcus. Emerg Infect Dis 6:175–179
    [Google Scholar]
  2. Department of Health 2001 Prevalence of HIV and Hepatitis Infections in the United Kingdom 2000 Unlinked Anonymous Surveys Steering Group London: Department of Health;
    [Google Scholar]
  3. Jones J. A, Salmon J. E, Djuretic T, Nichols G, George R. C, Gill O. N. 2002; An outbreak of serious illness and death among injecting drug users in England during 2000. J Med Microbiol 51:978–984
    [Google Scholar]
  4. Lechot P, Schaad H. J, Graf S, Täuber M, Mühlemann K. 2001; Group A streptococcus clones causing repeated epidemics and endemic disease in intravenous drug users. Scand J Infect Dis 33:41–46 [CrossRef]
    [Google Scholar]
  5. McLauchlin J, Mithani V, Bolton F. J, Nichols G. L, Bellis M. A, Syed Q, Thomson R. P. M, Ashton J. R. 2002; An investigation into the microflora of heroin. J Med Microbiol 51:1001–1008
    [Google Scholar]
  6. PHLS 2002; Group A streptococcal bacteraemia among injecting drug users. Commun Dis Rep CDR Wkly 12:3–4 online 2 January 2003 http://www.phls.org.uk/publications/cdr/pdffiles/2002/cdr2202.pdf
    [Google Scholar]
  7. Schalén C. 2002; European surveillance of severe group A streptococcal disease. Eurosurveillance Wkly 6020829 online 29 August 2002 http://www.eurosurveillance.org/ew/2002/020829.asp
    [Google Scholar]
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