1887

Abstract

Species of the genus () are opportunistic micro-organisms that are environmentally widespread saprophytes in soil and can, very rarely, be pathogenic in humans. Disseminated infection has been described in patients with immunodeficiency, but has previously been reported in only one neonate. A preterm infant with strictum fungaemia is reported here. The patient was born at 27 weeks gestation and weighed 870 g at birth. She needed intensive respiratory management and became septic on day 11 of life. Blood and cerebrospinal fluid (CSF) cultures were positive for . The patient did not respond to therapy with amphotericin B plus fluconazole and died on day 25 of life. The autopsy showed foci due to in the brain, liver and heart.

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2003-09-01
2024-11-09
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References

  1. Anadolu R, Hilmioglu S, Oskay T, Boyvat A, Peksari Y, Gürgey E. 2001; Indolent Acremonium strictum infection in an immunocompetent patient. Int J Dermatol 40:451–453 [CrossRef]
    [Google Scholar]
  2. Cole F. S. 1998; Infections and immunologic defence mechanisms. In Avery's Diseases of the Newborn , 7th edn. pp 435–540 Edited by Taeusch H. W., Ballard R. A., Fletcher J. Philadelphia: W. B. Saunders;
    [Google Scholar]
  3. Fincher R. M. E, Fisher J. F, Lovell R. D, Newman C. L, Espinel-Ingroff A, Shadomy H. J. 1991; Infection due to the fungus Acremonium ( Cephalosporium). Medicine 70398–409
    [Google Scholar]
  4. Fridkin S. K, Jarvis W. R. 1996; Epidemiology of nosocomial fungal infections. Clin Microbiol Rev 9:499–511
    [Google Scholar]
  5. Guarro J, Gams W, Pujol I, Gene J. 1997; Acremonium species: new emerging fungal opportunists –in vitro antifungal susceptibilities and review. Clin Infect Dis 25:1222–1229 [CrossRef]
    [Google Scholar]
  6. Jeffrey W. R, Hernandez J. E, Zarraga A. L, Oley G. E, Kitchen L. W. 1993; Disseminated infection due to Acremonium species in a patient with Addison's disease. Clin Infect Dis 16:170– 170 [CrossRef]
    [Google Scholar]
  7. Koç A. N, Utas C, Oymak O, Sehmen E. 1998; Peritonitis due to Acremonium strictum in a patient on continuous ambulatory peritoneal dialysis. Nephron 79:357–358 [CrossRef]
    [Google Scholar]
  8. Krcmery V, Fric M, Pisarcikova M. 7 other authors 2000; Fungemia in neonates: report of 80 cases from seven University hospitals. Pediatrics 105:913–914 [CrossRef]
    [Google Scholar]
  9. Lau Y. L, Yuen K. Y, Lee C. W, Chan C. F. 1995; Invasive Acremonium falciforme infection in a patient with severe combined immunodeficiency. Clin Infect Dis 20:197–198 [CrossRef]
    [Google Scholar]
  10. Makhoul I. R, Kassis I, Smolkin T, Tamir A, Sujov P. 2001; Review of 49 neonates with acquired fungal sepsis: further characterization. Pediatrics 107:61–66 [CrossRef]
    [Google Scholar]
  11. Nedret Koç A, Erdem F, Patiroglu T. 2002; Case report. Acremonium falciforme fungemia in a patient with acute leukaemia. Mycoses 45:202–203 [CrossRef]
    [Google Scholar]
  12. Papadatos C, Pavlatou N, Alexiou D. 1969; Cephalosporium meningitis. Pediatrics 44:749–751
    [Google Scholar]
  13. Schell W. A, Perfect J. R. 1996; Fatal, disseminated Acremonium strictum infection in a neutropenic host. J Clin Microbiol 34:1333–1336
    [Google Scholar]
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