1887

Abstract

, an intracellular bacterium, is associated with respiratory diseases, reinfectivity and chronic diseases such as cardiovascular disease, hypertension and stroke. The risk of infection is higher and infections are a serious clinical problem in patients with type 1 (insulin-dependent) diabetes mellitus (T1DM). Although diabetes mellitus and hyperglycaemia are considered possible risk factors for various types of aetiological agents, the epidemiological evidence concerning infection is scanty. The aim of the present study was to evaluate the impact of glycosylated haemoglobin (HbA1c) levels, an indicator of a hyperglycaemic state, on infection and disease chronicity; in addition we compared the duration of diabetes with the occurrence of infection. blood real time PCR and serology (IgG, IgA and IgM) assays by an ELISA method were performed. DNA was detected in 46.5 % [95 % confidence interval (CI) = 35.1–57.9 %] of the patients with T1DM; this prevalence is higher (<0.05) than in non-diabetic paediatric controls, 10.5 % (95 % CI = 3.6–17.4 %). IgG/IgA antibody positivity was significantly (≤0.05) more common in patients in poor metabolic control (HbA1c >9 %) versus patients in good metabolic control (HbA1c <7 %), suggesting that the metabolic control of the disease is compromised in the patients with T1DM. In conclusion, adolescents with T1DM were more likely to show signs of infection with compared with healthy adolescents and the results suggest an increased risk of progressing from an acute infection to a chronic form.

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2012-11-01
2024-12-14
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