1887

Abstract

Echinocandins are first-line agents for treating severe invasive candidiasis. Glucan synthase gene () mutations lead to echinocandin resistance but the role of enhanced chitin expression is not well recognized in clinical isolates. We report a case of bloodstream infection with both Fks1 hotspot mutation and elevated cell wall chitin.

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2012-09-01
2019-10-16
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References

  1. Ben-Ami R. , Garcia-Effron G. , Lewis R. E. , Gamarra S. , Leventakos K. , Perlin D. S. , Kontoyiannis D. P. . ( 2011; ). Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance. . J Infect Dis 204:, 626–635. [CrossRef] [PubMed]
    [Google Scholar]
  2. Chalmers C. M. , Bal A. M. . ( 2011; ). Management of fungal infections in the intensive care unit: a survey of UK practice. . Br J Anaesth 106:, 827–831. [CrossRef] [PubMed]
    [Google Scholar]
  3. Costa-de-Oliveira S. , Marcos Miranda I. , Silva R. M. , Pinto E Silva A. , Rocha R. , Amorim A. , Gonçalves Rodrigues A. , Pina-Vaz C. . ( 2011; ). FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy. . Antimicrob Agents Chemother 55:, 1312–1314. [CrossRef] [PubMed]
    [Google Scholar]
  4. Dannaoui E. , Desnos-Ollivier M. , Garcia-Hermoso D. , Grenouillet F. , Cassaing S. , Baixench M. T. , Bretagne S. , Dromer F. , Lortholary O. . French Mycoses Study Group ( 2012; ). Candida spp. with acquired echinocandin resistance, France, 2004–2010. . Emerg Infect Dis 18:, 86–90. [CrossRef] [PubMed]
    [Google Scholar]
  5. Garcia-Effron G. , Park S. , Perlin D. S. . ( 2009; ). Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints. . Antimicrob Agents Chemother 53:, 112–122. [CrossRef] [PubMed]
    [Google Scholar]
  6. Garcia-Effron G. , Chua D. J. , Tomada J. R. , DiPersio J. , Perlin D. S. , Ghannoum M. , Bonilla H. . ( 2010; ). Novel FKS mutations associated with echinocandin resistance in Candida species. . Antimicrob Agents Chemother 54:, 2225–2227. [CrossRef] [PubMed]
    [Google Scholar]
  7. Kofteridis D. P. , Lewis R. E. , Kontoyiannis D. P. . ( 2010; ). Caspofungin-non-susceptible Candida isolates in cancer patients. . J Antimicrob Chemother 65:, 293–295. [CrossRef] [PubMed]
    [Google Scholar]
  8. Lee K. K. , Maccallum D. M. , Jacobsen M. D. , Walker L. A. , Odds F. C. , Gow N. A. , Munro C. A. . ( 2012; ). Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo. . Antimicrob Agents Chemother 56:, 208–217. [CrossRef] [PubMed]
    [Google Scholar]
  9. Pappas P. G. , Kauffman C. A. , Andes D. , Benjamin D. K. Jr , Calandra T. F. , Edwards J. E. Jr , Filler S. G. , Fisher J. F. , Kullberg B. J. . & other authors ( 2009; ). Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. . Clin Infect Dis 48:, 503–535. [CrossRef] [PubMed]
    [Google Scholar]
  10. Park S. , Kelly R. , Kahn J. N. , Robles J. , Hsu M. J. , Register E. , Li W. , Vyas V. , Fan H. . & other authors ( 2005; ). Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates. . Antimicrob Agents Chemother 49:, 3264–3273. [CrossRef] [PubMed]
    [Google Scholar]
  11. Parkins M. D. , Sabuda D. M. , Elsayed S. , Laupland K. B. . ( 2007; ). Adequacy of empirical antifungal therapy and effect on outcome among patients with invasive Candida species infections. . J Antimicrob Chemother 60:, 613–618. [CrossRef] [PubMed]
    [Google Scholar]
  12. Pfeiffer C. D. , Garcia-Effron G. , Zaas A. K. , Perfect J. R. , Perlin D. S. , Alexander B. D. . ( 2010; ). Breakthrough invasive candidiasis in patients on micafungin. . J Clin Microbiol 48:, 2373–2380. [CrossRef] [PubMed]
    [Google Scholar]
  13. Ruhnke M. , Rickerts V. , Cornely O. A. , Buchheidt D. , Glöckner A. , Heinz W. , Höhl R. , Horré R. , Karthaus M. . & other authors ( 2011; ). Diagnosis and therapy of Candida infections: joint recommendations of the German Speaking Mycological Society and the Paul-Ehrlich-Society for Chemotherapy. . Mycoses 54:, 279–310. [CrossRef] [PubMed]
    [Google Scholar]
  14. Schelenz S. , Barnes R. A. , Kibbler C. C. , Jones B. L. , Denning D. W. . ( 2009; ). Standards of care for patients with invasive fungal infections within the United Kingdom: a national audit. . J Infect 58:, 145–153. [CrossRef] [PubMed]
    [Google Scholar]
  15. Schuster M. G. , Edwards J. E. Jr , Sobel J. D. , Darouiche R. O. , Karchmer A. W. , Hadley S. , Slotman G. , Panzer H. , Biswas P. , Rex J. H. . ( 2008; ). Empirical fluconazole versus placebo for intensive care unit patients: a randomized trial. . Ann Intern Med 149:, 83–90.[PubMed] [CrossRef]
    [Google Scholar]
  16. Walker L. A. , Munro C. A. , de Bruijn I. , Lenardon M. D. , McKinnon A. , Gow N. A. . ( 2008; ). Stimulation of chitin synthesis rescues Candida albicans from echinocandins. . PLoS Pathog 4:, e1000040. [CrossRef] [PubMed]
    [Google Scholar]
  17. Walker L. A. , Gow N. A. , Munro C. A. . ( 2010; ). Fungal echinocandin resistance. . Fungal Genet Biol 47:, 117–126. [CrossRef] [PubMed]
    [Google Scholar]
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