1887

Abstract

Mobile drug-resistance genes with identical nucleic acid sequences carried by multidrug-resistant strains that cause community-acquired infections are becomingly increasingly dispersed worldwide. Over a 2-year period, we analysed Gram-negative bacterial (GNB) pathogens from the blood of inpatients at an urban public hospital to determine what proportion of these isolates carried such globally dispersed drug-resistance genes. Of 376 GNB isolates, 167 (44 %) were , 50 (13 %) were , 25 (7 %) were , 25 (7 %) were and 20 (5 %) were ; the remainder (24 %) comprised 26 different GNB species. Among isolates, class 1 integrons were detected in 64 (38 %). The most common integron gene cassette configuration was , found in 30 (25 %) of 119 drug-resistant isolates and in one isolate of . Extended-spectrum β-lactamase (ESBL) genes were found in 16 isolates (10 %). These genes with identical sequences were found in nearly 40 % of bloodstream isolates in the study hospital, as well as in a variety of bacterial species from clinical and non-clinical sources worldwide. Thus, a substantial proportion of bloodstream infections among hospitalized patients were caused by strains carrying drug-resistance genes that are dispersed globally in a wide variety of bacterial species.

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2012-07-01
2020-09-28
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