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Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 61, Issue 1

Infection with strains lacking is associated with an increased risk of gastric ulcer and gastric cancer development No Access

Abstract

Recently, was reported as a new virulence factor in , but its association with gastroduodenal disorders and its mode of action are still unclear. Here, an association of the status with different disease groups was determined and a biological explanation for the observed associations was tested. In total, 216 isolates were obtained from 232 presumed -infected patients. A positive association was observed between the occurrence of duodenal ulcer (DU) and the presence of [odds ratio (OR) 24.2; 95 % confidence interval (CI) 10.6–54.8]. In addition, an inverse association between the occurrence of gastric cancer (GC) [OR 0.16; 95 % CI 0.05–0.47] and gastric ulcer (GU) [OR 0.34; 95 % CI 0.16–0.68] with the presence of was observed. A putative explanation for the observed associations might be a more corpus-located infection (pan-gastritis) by the -positive strains due to their increased acid resistance. Indeed, a strong association between -positive isolated from gastritis patients and acid resistance was observed (<0.05). The observed higher acid resistance of the -positive strains suggests that these strains are adapted to a stomach with high gastric acid output. This may in part explain the observed associations, as an increased gastric acid output is thought to be typical for an antrum-predominant infection and, whilst this is associated with an increased risk of DU formation, it also decreases the risk for the genesis of GUs and GC.

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© 2012 SGM
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2012-01-01
2025-04-23
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Infection with Helicobacter pylori strains lacking dupA is associated with an increased risk of gastric ulcer and gastric cancer development
J. Med. Microbiol. 61, 23 (2012); https://doi.org/10.1099/jmm.0.027052-0
/content/journal/jmm/10.1099/jmm.0.027052-0
/content/journal/jmm/10.1099/jmm.0.027052-0
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