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Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 59, Issue 4

Spread of community-acquired meticillin-resistant skin and soft-tissue infection within a family: implications forantibiotic therapy and prevention No Access

Abstract

Outbreaks or clusters of community-acquired meticillin-resistant (CA-MRSA) within families have been reported. We describea family cluster of CA-MRSA skin and soft-tissue infection where CA-MRSA wassuspected because of recurrent infections which failed to respond to flucloxacillin.While the prevalence of CA-MRSA is low worldwide, CA-MRSA should be consideredin certain circumstances depending on clinical presentation and risk assessment.Surveillance cultures of family contacts of patients with MRSA should be consideredto help establish the prevalence of CA-MRSA and to inform the optimal choiceof empiric antibiotic treatment.

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Keyword(s): CA-MRSA, community-acquired meticillin-resistant Staphylococcus aureus , HA-MRSA, healthcare-associated MRSA , MLST, multilocus sequence type , PVL, Panton–Valentineleukocidin , SCCmec, staphylococcal cassette chromosome mec and SSTI, skin and soft-tissue infection
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/content/journal/jmm/10.1099/jmm.0.015925-0
2010-04-01
2025-02-11
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References

  1. Adhikari R. P., Cook G. M., Lamont I., Lang S., Heffernan H., Smith J. M. 2002; Phenotypic and molecularcharacterization of community occurring, Western Samoan phage pattern methicillin-resistant Staphylococcus aureus . J Antimicrob Chemother 50:825–831 [CrossRef]
     [Google Scholar]
  2. CLSI 2007 Performance Standardsfor Antimicrobial Susceptibility Testing ; Sixteenth Informational Supplement.CLSI Document M100-S16 Wayne, PA: Clinical and Laboratory Standards Institute;
     [Google Scholar]
  3. CLSI 2009 Performance Standardsfor Antimicrobial Susceptibility Testing ; Sixteenth Informational Supplement.CLSI Document M100-S16 Wayne, PA: Clinical and Laboratory Standards Institute;
     [Google Scholar]
  4. Cosgrove S. E., Sakoulas G., Perencevich E. N., Schwaber M. J., Karchmer A. W., Carmeli Y. 2003; Comparisonof mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteraemia: a meta-analysis. Clin InfectDis 36:53–59
     [Google Scholar]
  5. Davis K. A., Stewart J. J., Crouch H. K., Florez C. E., Hospenthal D. R. 2004; Methicillin-resistant Staphylococcus aureus (MRSA) nares colonisation at hospitaladmission and its effect on subsequent MRSA infection. Clin InfectDis 39:776–782
     [Google Scholar]
  6. Deurenberg R. H., Stobberingh E. E. 2009; The molecular evolution of hospital- and community-associatedmethicillin-resistant Staphylococcus aureus . Curr MolMed 9:100–115
     [Google Scholar]
  7. Diep B. A., Palazzolo-Ballance A. M., Tattevin P, Basuino L., Braughton K. R., Whitney A. R., Chen L, Kreiswirth B. N., Otto M. other authors 2008; Contribution of Panton-Valentineleukocidin in community-associated methicillin-resistant Staphylococcusaureus pathogenesis. PLoS One 3:e3198 [CrossRef]
     [Google Scholar]
  8. Dufour P., Gillet Y., Bes M., Lina G., Vandenesch F., Floret D., Etienne J., Richet H. 2002; Community-acquiredmethicillin-resistant Staphylococcus aureus infection in France: emergence of a single clone that produces Panton-Valentine leukocidin. Clin Infect Dis 35:819–824 [CrossRef]
     [Google Scholar]
  9. Gillet Y., Issartel B., Vanhems P., Fournet J. C., Lina G., Bes M., Vandenesch F., Piémont Y., Brousse N. other authors 2002; Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethalnecrotising pneumonia in young immunocompetent patients. Lancet 359:753–759 [CrossRef]
     [Google Scholar]
  10. Gorak E. J., Yamada S. M., Brown J. D. 1999; Community-acquired methicillin-resistant Staphylococcusaureus in hospitalized adults and children without known risk factors. Clin Infect Dis 29:797–800 [CrossRef]
     [Google Scholar]
  11. HPA 2008; Guidance on the diagnosisand management of PVL-associated Staphylococcus aureus infections (PVL-SA)in England. Report prepared by the PVL sub-group of the Steering Group onHealthcare Associated Infection http://www.hpa.org.uk/web/HPAwebFile/HPAweb_C/1218699411960
  12. Jones T. F., Creech C. B., Erwin P., Baird S. G., Woron A. M., Schaffner W. 2006; Family outbreaksof invasive community-associated methicillin-resistant Staphylococcusaureus infection. Clin Infect Dis 42:e76–e78 [CrossRef]
     [Google Scholar]
  13. Kluytmans J., van Belkum A., Verbrugh H. 1997; Nasal carriage of Staphylococcus aureus epidemiology,underlying mechanisms, and associated risks. Clin Microbiol Rev 10:505–520
     [Google Scholar]
  14. Kronvall G, Karlsson I, Walder M, Sörberg M, Nilsson L. E. 2006; Epidemiological MIC cut-offvalues for tigecycline calculated from Etest MIC values using normalized resistanceinterpretation. J Antimicrob Chemother 57:498–505 [CrossRef]
     [Google Scholar]
  15. Labandeira-Rey M., Couzon F., Boisset S., Brown E. L., Bes M., Benito Y., Barbu E. M., Vazquez V., Höök M., otherauthors. 2007; Staphylococcus aureus Panton-Valentineleukocidin causes necrotizing pneumonia. Science 315:1130–1133 [CrossRef]
     [Google Scholar]
  16. Larsen A. R., Stegger M., Bocher S., Sorum M., Monnet D.L., Skov R. L. 2009; Emergence and characterizationof community-associated methicillin-resistant Staphylococcus aureus infections in Denmark 1999–2006. J Clin Microbiol 47:73–78 [CrossRef]
     [Google Scholar]
  17. Naimi T. S., Ledell K. H., Como-Sabetti K, Borchardt S.M., Boxrud D. J., Etienne J, Johnson S. K., Vandenesch F, Fridkin S. other authors 2003; Comparison of community- andhealthcare- associated methicillin-resistant Staphylococcus aureus infection. JAMA 290:2976–2984 [CrossRef]
     [Google Scholar]
  18. Okuma K, Iwakawa K, Turnidge J. D., Grubb W. B., Bell J. M., O'Brien F. G., Coombs G. W., Pearman J. W., Tenover F. C. other authors 2002; Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol 40:4289–4294 [CrossRef]
     [Google Scholar]
  19. Otter J. A., Havill N. L., Boyce J. M., French G. L. 2009; Comparison of community-associated methicillin-resistant Staphylococcus aureus from teaching hospitals in London and the USA,2004–2006: where is USA300 in the UK?. Eur J Clin MicrobiolInfect Dis 28:835–839
     [Google Scholar]
  20. Popovich K. J., Hota B. 2008).Treatment; and prevention of community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections. DermatolTher 21:167–179
     [Google Scholar]
  21. Rossney A. S., Lawrence M. J., Morgan P. M., Fitzgibbon M. M., Shore A., Coleman D. C., Keane C. T., O'Connell B. 2006; Epidemiological typing of MRSA isolates from bloodcultures taken in Irish hospitals participating in the European AntimicrobialResistance Surveillance System (1999–2003. EurJ Clin Microbiol Infect Dis 25:79–89
     [Google Scholar]
  22. Rossney A. S., Shore A. C., Morgan P. M., Fitzgibbon M.M., O'Connell B., Coleman D. C. 2007).The; emergence and importation of diverse genotypes of methicillin-resistant Staphylococcus aureus (MRSA) harbouring the Panton-Valentineleukocidin gene ( pvl ) reveal that pvl is a poormarker for community-associated MRSA strains in Ireland. J ClinMicrobiol 45:2554–2563
     [Google Scholar]
  23. Salgado C. D., Farr B. M., Calfee D. P. 2003; Community-acquired methicillin-resistant Staphylococcusaureus : a meta-analysis of prevalence and risk factors. ClinInfect Dis 36:131–139
     [Google Scholar]
  24. Sdougkos G, Chini V, Papanastasiou D. A., Christodoulou G., Stamatakis E., Vris A., Christodoulidi I., Protopapadakis G., Spiliopoulouet I. 2008; Community-associated Staphylococcus aureus infections and nasal carriage among children: molecularmicrobial data and clinical characteristics. Clin Microbiol Infect 14:995–1001 [CrossRef]
     [Google Scholar]
  25. Tseng C. W., Kyme P., Low J., Rocha M. A., Alsabeh R., Miller L. G., Otto M., Arditi M., Diep B. A. other authors 2009; Staphylococcus aureus Panton-Valentine leukocidincontributes to inflammation and muscle tissue injury. PLoS One 4:e6387 [CrossRef]
     [Google Scholar]
  26. Vandenesch F., Naimi T., Enright M. C., Lina G., Nimmo G. R., Heffernan H., Liassine N., Bes M., Greenland T. other authors 2003; Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwideemergence. Emerg Infect Dis 9:978–984 [CrossRef]
     [Google Scholar]
  27. Vourli S., Vagiakou H., Ganteris G., Orfanidou M., Polemis M., Vatopoulos A., Malamou-Ladas H. 2009; High rates of community-acquired, Panton-Valentine leukocidin (PVL)-positivemethicillin-resistant S. aureus (MRSA) infections in adultoutpatients in Greece. Euro Surveill 14
     [Google Scholar]
  28. Weber J. T. 2005; Community-associatedmethicillin-resistant Staphylococcus aureus . Clin InfectDis 41:S269–S272
     [Google Scholar]
  29. Zafar U., Johnson L. B., Hanna M., Riederer K., Sharma M., Fakih M. G., Thirumoorthi M. C., Farjo R., Khatib R. 2007; Prevalence of nasal colonization among patients withcommunity-associated methicillin-resistant Staphylococcus aureus infection and their household contacts. Infect Control Hosp Epidemiol 28:966–999 [CrossRef]
     [Google Scholar]
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