1887

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Volume 58, Issue 10

Frequency and molecular characteristics of ciprofloxacin- and rifampicin-resistant from gastric infections in the UK Free

Abstract

Treatment failure with standard eradication regimes may require the use of ‘rescue’ therapies containing fluoroquinolones or rifamycins. The susceptibilities of in the UK to such antimicrobials are unknown; therefore, this study aimed to determine the frequencies and molecular markers of resistance. Ciprofloxacin and rifampicin susceptibilities were determined by Etest and/or disc diffusion for 255 isolates of , including 171 isolates from adult dyspeptic patients with refractive infections. Mutations in known resistance-determining regions of and were determined. The ciprofloxacin resistance rate was 7.5 %, and mutations, predominantly at codon position 91, were identified in most resistant isolates. One isolate (<1 %) had an unequivocal rifampicin-resistant phenotype by Etest yet had no associated mutations in the gene. As resistance rates were low in isolates, including those from patients with refractive infections, it was concluded that fluoroquinolones or rifamycins might be considered in the UK for inclusion in ‘rescue’ therapies.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): QRDR, quinolone resistance-determining region
SGM
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2009-10-01
2024-04-26
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Frequency and molecular characteristics of ciprofloxacin- and rifampicin-resistant Helicobacter pylori from gastric infections in the UK
J. Med. Microbiol. 58, 1322 (2009); https://doi.org/10.1099/jmm.0.011270-0
/content/journal/jmm/10.1099/jmm.0.011270-0
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