1887

Abstract

is an important pathogen of man, but is also able to colonize and cause disease in a wide variety of mammals and birds. An extended multilocus sequencing approach, involving multilocus sequence typing (MLST), typing, typing and typing, was used to examine the molecular diversity of 118 isolates recovered from a range of host species and to compare these data with the known diversity of human-derived isolates. MLST revealed that the commonest animal-associated MLST types were ST133, ST5, ST71, ST97, ST126 and ST151. ST133 appears to be an ungulate-animal-specific genotype, as no evidence of ST133 associating with humans has yet been found in the literature. Novel and unique alleles were identified in the animal-associated strains that may represent animal-associated alleles. However, typing exhibited a lower typeability than MLST for the animal strains (91.3 %). Phylogenetic analyses using neighbour-joining and maximum-parsimony trees localized ruminant-associated MLST lineages to both previously identified subspecies subgroups, thus explaining the finding of all four types within the ruminant-associated strains. isolates recovered from chickens and rabbits were genotypically more similar to known human genotypes than the ruminant-associated lineages.

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2009-10-01
2019-11-20
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vol. , part 10, pp. 1343-1353

Genotypic characteristics of the strains in the study, and Additional clonal complexes containing previously identified animal-associated sequence types. [PDF](523 KB)



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