1887

Abstract

The alarming spread of multiple drug resistance in , combined with the frequent occurrence of and in biofilm-type infections, indicates a growing need for new therapies. The experimental steroidal amide anprocide [3-acetoxy-17-(-prolyl)amino-5-androstane] significantly reduced c.f.u. ml per suture ( <0.0001) in a murine model of topical infection. In chequerboard assays with planktonic-grown and , anprocide was synergistic with bacitracin, oxacillin, clindamycin or ceftriaxone. Anprocide was also synergistic in combination with bacitracin or oxacillin against some isolates of biofilm-grown and .

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2009-09-01
2020-04-07
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