1887

Abstract

This study was performed to assess the prevalence and genotypes of plasmid-borne extended-spectrum -lactamases (ESBLs) and AmpC -lactamases in in Korea. A total of 576 isolates of was collected from 12 Korean hospitals during May and July 2007. A phenotypic confirmatory test detected ESBLs in 82 (14.2 %) of the 576 isolates. The most common types of ESBLs identified were CTX-M-14 (=32) and CTX-M-15 (=27). The prevalence and diversity of the CTX-M mutants, including CTX-M-15, CTX-M-27 and CTX-M-57, with significant hydrolytic activity against ceftazidime were increased. PCR experiments detected genes encoding plasmid-borne AmpC -lactamases in 15/56 cefoxitin-intermediate or cefoxitin-resistant isolates, and the most common type of AmpC -lactamase identified was DHA-1 (=10). These data suggest that the incidence of ESBLs in has increased as a result of the dissemination of CTX-M enzymes in Korea. In addition, CTX-M-22, CTX-M-27 and CTX-M-57 have appeared in Korea.

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2009-02-01
2020-04-07
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