1887

Abstract

isolates causing invasive disease at a large tertiary institute in Singapore from 2000 to 2007 were serotyped, with 84 (43.8 %) and 159 (82.8 %) isolates belonging to serotypes covered by the pneumococcal heptavalent conjugate and polysaccharide vaccines, respectively. All non-meningitis isolates were susceptible to penicillin, and the attributable mortality was 21.4 %. Patients who fulfilled the US Advisory Committee on Immunization Practices criteria for vaccination with the pneumococcal polysaccharide vaccine comprised 74.0 % of the study cohort and had a significantly higher mortality risk.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.003764-0
2009-01-01
2019-10-13
Loading full text...

Full text loading...

/deliver/fulltext/jmm/58/1/101.html?itemId=/content/journal/jmm/10.1099/jmm.0.003764-0&mimeType=html&fmt=ahah

References

  1. Adam, D. ( 2002; ). Global antibiotic resistance in Streptococcus pneumoniae. J Antimicrob Chemother 50 (Suppl.), 1–5.
    [Google Scholar]
  2. ACIP ( 1997; ). Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 46 (RR-8), 1–24.
    [Google Scholar]
  3. Albrich, W. C., Baughman, W., Schmotzer, B. & Farley, M. M. ( 2007; ). Changing characteristics of invasive pneumococcal disease in Metropolitan Atlanta, Georgia, after introduction of a 7-valent pneumococcal conjugate vaccine. Clin Infect Dis 44, 1569–1576.[CrossRef]
    [Google Scholar]
  4. Balakrishnan, I., Crook, P., Morris, R. & Gillespie, S. H. ( 2000; ). Early predictors of mortality in pneumococcal bacteraemia. J Infect 40, 256–261.[CrossRef]
    [Google Scholar]
  5. Black, S., Shinefield, H., Baxter, R., Austrian, R., Elvin, L., Hansen, J., Lewis, E. & Fireman, B. ( 2006; ). Impact of the use of heptavalent pneumococcal conjugate vaccine on disease epidemiology in children and adults. Vaccine 24 (Suppl. 2), S79–S80
    [Google Scholar]
  6. CDC ( 2005; ). Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease – United States, 1998–2003. MMWR Morb Mortal Wkly Rep 54, 893–897.
    [Google Scholar]
  7. Chong, C. Y., Mok, Y. H. & Tee, N. ( 2006; ). Invasive pneumococcal disease in Singapore children. Poster presented at the 5th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPDS), Alice Springs, Australia.
  8. CLSI ( 2008; ). Performance Standards for Antimicrobial Susceptibility Testing. Eighteenth Informational Supplement, M100-S18. Wayne, PA: Clinical and Laboratory Standards Institute.
  9. Hicks, L. A., Harrison, L. H., Flannery, B., Hadler, J. L., Schaffner, W., Craig, A. S., Jackson, D., Thomas, A., Beall, B. & other authors ( 2007; ). Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination. J Infect Dis 196, 1346–1354.[CrossRef]
    [Google Scholar]
  10. Low, S., Chan, F. L. F., Cutter, J., Ma, S., Goh, K. T. & Chew, S. K. ( 2007; ). A national study of the epidemiology of pneumococcal disease among hospitalised patients in Singapore: 1995 to 2004. Singapore Med J 48, 824–829.
    [Google Scholar]
  11. Pai, R., Gertz, R. E. & Beall, B. ( 2006; ). Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolates. J Clin Microbiol 44, 124–131.[CrossRef]
    [Google Scholar]
  12. Plouffe, J. F., Breiman, R. F., & Facklam, R. R., Franklin County Pneumonia Study Group ( 1996; ). Bacteremia with Streptococcus pneumoniae. Implications for therapy and prevention. JAMA 275, 194–198.[CrossRef]
    [Google Scholar]
  13. Singapore Department of Statistics ( 2007; ). Online Yearbook of Statistics Singapore 2007, http://www.singstat.gov.sg/pubn/reference/yos/statsT-demography.pdf (accessed on 1 May 2008).
  14. Soh, S. W., Poh, C. L. & Lin, R. V. ( 2000; ). Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates from pediatric patients in Singapore. Antimicrob Agents Chemother 44, 2193–2196.[CrossRef]
    [Google Scholar]
  15. Song, J. H., Jung, S. I., Ko, K. S., Kim, N. Y., Son, J. S., Chang, H. H., Ki, H. K., Oh, W. S., Suh, J. Y. & other authors ( 2004; ). High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study). Antimicrob Agents Chemother 48, 2101–2107.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.003764-0
Loading
/content/journal/jmm/10.1099/jmm.0.003764-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error