1887

Abstract

isolates causing invasive disease at a large tertiary institute in Singapore from 2000 to 2007 were serotyped, with 84 (43.8 %) and 159 (82.8 %) isolates belonging to serotypes covered by the pneumococcal heptavalent conjugate and polysaccharide vaccines, respectively. All non-meningitis isolates were susceptible to penicillin, and the attributable mortality was 21.4 %. Patients who fulfilled the US Advisory Committee on Immunization Practices criteria for vaccination with the pneumococcal polysaccharide vaccine comprised 74.0 % of the study cohort and had a significantly higher mortality risk.

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2009-01-01
2024-04-26
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References

  1. Adam D. 2002; Global antibiotic resistance in Streptococcus pneumoniae . J Antimicrob Chemother 50:Suppl.1–5
    [Google Scholar]
  2. ACIP 1997; Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 46 (RR-8):1–24
    [Google Scholar]
  3. Albrich W. C., Baughman W., Schmotzer B., Farley M. M. 2007; Changing characteristics of invasive pneumococcal disease in Metropolitan Atlanta, Georgia, after introduction of a 7-valent pneumococcal conjugate vaccine. Clin Infect Dis 44:1569–1576 [CrossRef]
    [Google Scholar]
  4. Balakrishnan I., Crook P., Morris R., Gillespie S. H. 2000; Early predictors of mortality in pneumococcal bacteraemia. J Infect 40:256–261 [CrossRef]
    [Google Scholar]
  5. Black S., Shinefield H., Baxter R., Austrian R., Elvin L., Hansen J., Lewis E., Fireman B. 2006; Impact of the use of heptavalent pneumococcal conjugate vaccine on disease epidemiology in children and adults. Vaccine 24 (Suppl. 2):S79–S80
    [Google Scholar]
  6. CDC 2005; Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease – United States, 1998–2003. MMWR Morb Mortal Wkly Rep 54:893–897
    [Google Scholar]
  7. Chong C. Y., Mok Y. H., Tee N. 2006; Invasive pneumococcal disease in Singapore children. Poster presented at the 5th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPDS) Alice Springs, Australia:
    [Google Scholar]
  8. CLSI 2008 Performance Standards for Antimicrobial Susceptibility Testing . Eighteenth Informational Supplement, M100-S18 Wayne, PA: Clinical and Laboratory Standards Institute;
    [Google Scholar]
  9. Hicks L. A., Harrison L. H., Flannery B., Hadler J. L., Schaffner W., Craig A. S., Jackson D., Thomas A., Beall B. other authors 2007; Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination. J Infect Dis 196:1346–1354 [CrossRef]
    [Google Scholar]
  10. Low S., Chan F. L. F., Cutter J., Ma S., Goh K. T., Chew S. K. 2007; A national study of the epidemiology of pneumococcal disease among hospitalised patients in Singapore: 1995 to 2004. Singapore Med J 48:824–829
    [Google Scholar]
  11. Pai R., Gertz R. E., Beall B. 2006; Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolates. J Clin Microbiol 44:124–131 [CrossRef]
    [Google Scholar]
  12. Plouffe J. F., Breiman R. F., Facklam R. R. Franklin County Pneumonia Study Group 1996; Bacteremia with Streptococcus pneumoniae . Implications for therapy and prevention. JAMA 275:194–198 [CrossRef]
    [Google Scholar]
  13. Singapore Department of Statistics 2007; Online Yearbook of Statistics Singapore 2007 . (accessed on 1 May 2008 http://www.singstat.gov.sg/pubn/reference/yos/statsT-demography.pdf
  14. Soh S. W., Poh C. L., Lin R. V. 2000; Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates from pediatric patients in Singapore. Antimicrob Agents Chemother 44:2193–2196 [CrossRef]
    [Google Scholar]
  15. Song J. H., Jung S. I., Ko K. S., Kim N. Y., Son J. S., Chang H. H., Ki H. K., Oh W. S., Suh J. Y. other authors 2004; High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study). Antimicrob Agents Chemother 48:2101–2107 [CrossRef]
    [Google Scholar]
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