1887

Abstract

Eighty per cent of the cases of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) have an infective aetiology, atypical bacteria including accounting for 5–10 % of these. However, the importance of association of with episodes of AECOPD still remains doubtful. The present study was therefore undertaken to delineate the extent of involvement of in patients with AECOPD at a referral hospital in Delhi, India. Sputum samples and throat swabs from a total of 100 AECOPD patients attending the Clinical Research Center of Vallabhbhai Patel Chest Institute, Delhi, were collected during a 2-year period (January 2004–June 2006). The samples were investigated for the presence of aerobic bacterial pathogens and . Diagnosis of infection with was based on culture, serology, direct detection of specific antigen and PCR. Bacterial aetiology could be established in 16 of the 100 samples studied. spp. were recovered from eight cases, from four and spp. from two cases. sp. and were isolated from one case each. Serological evidence of infection and/or detection of specific antigen were seen in 16 % of the cases. One case with definite evidence of infection also had coinfection with spp. However, no direct evidence of infection was found in our study population as defined by culture isolation or PCR. In conclusion, although the serological prevalence of infection in our study population was significantly higher than in the control group, there was no direct evidence of it playing a role in AECOPD.

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2009-03-01
2019-10-15
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