1887

Abstract

The Gram-negative bacterium is the causative agent of pleuropneumonia in pigs, its only known natural host. Typical symptoms of peracute disease include fever, apathy and anorexia, and time from infection to death may only be 6 h. Severe lung lesions result from presence of one or two of the ApxI-III toxins. Control is through good husbandry practice, vaccines and antibiotic use. Culture and presence of the species-specific gene by PCR confirms diagnosis, and identification of serovar, of which 19 are known, informs on appropriate vaccine use and epidemiology.

Funding
This study was supported by the:
  • Biotechnology and Biological Sciences Research Council (Award BB/S019901/1)
    • Principle Award Recipient: NotApplicable
  • Biotechnology and Biological Sciences Research Council (Award BB/S005897/1)
    • Principle Award Recipient: PaulLangford
  • Biotechnology and Biological Sciences Research Council (Award BB/S002103/1)
    • Principle Award Recipient: PaulLangford
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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/content/journal/jmm/10.1099/jmm.0.001483
2022-03-09
2024-04-26
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References

  1. Shope RE. Porcine contagious pleuropneumonia I. Experimental transmission, etiology and pathology. J Exp Med 1964; 119:357–368 [View Article] [PubMed]
    [Google Scholar]
  2. Pohl S, Bertschinger HU, Frederiksen W, Mannheim W. Transfer of Haemophilus pleuropneumoniae and the Pasteurella haemolytica-like organism causing porcine necrotic pleuropneumonia to the genus Actinobacillus (Actinobacillus pleuropneumoniae comb. nov.) on the basis of phenotypic and deoxyribonucleic acid relatedness. Int J of Syst Bacteriol 1983; 33:510–514 [View Article]
    [Google Scholar]
  3. Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW et al. Diseases of Swine, 11th ed. Hoboken, NJ: Wiley-Blackwell; 2019 pp 749–766 [View Article]
    [Google Scholar]
  4. Stringer OW, Bossé JT, Lacouture S, Gottschalk M, Fodor L et al. Proposal of Actinobacillus pleuropneumoniae serovar 19, and reformulation of previous multiplex PCRs for capsule-specific typing of all known serovars. Vet Microbiol 2021; 255:109021 [View Article] [PubMed]
    [Google Scholar]
  5. Foote SJ, Bossé JT, Bouevitch AB, Langford PR, Young NM et al. The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b). J Bacteriol 2008; 190:1495–1496 [View Article] [PubMed]
    [Google Scholar]
  6. Xu Z, Chen X, Li L, Li T, Wang S et al. Comparative genomic characterization of Actinobacillus pleuropneumoniae. J Bacteriol 2010; 192:5625–5636 [View Article] [PubMed]
    [Google Scholar]
  7. Stringer OW, Bossé JT, Lacouture S, Gottschalk M, Fodor L et al. Rapid detection and typing of Actinobacillus pleuropneumoniae serovars directly from clinical samples: Combining FTA® card technology with multiplex PCR. Front Vet Sci 2021; 8:728660 [View Article] [PubMed]
    [Google Scholar]
  8. To H, Teshima K, Kon M, Yasuda S, Akaike Y et al. Characterization of nontypeable Actinobacillus pleuropneumoniae isolates. J Vet Diagn Invest 2020; 32:581–584 [View Article] [PubMed]
    [Google Scholar]
  9. Sassu EL, Bossé JT, Tobias TJ, Gottschalk M, Langford PR et al. Update on Actinobacillus pleuropneumoniae-knowledge, gaps and challenges. Transbound Emerg Dis 2018; 65 Suppl 1:72–90 [View Article] [PubMed]
    [Google Scholar]
  10. Michael GB, Bossé JT, Schwarz S. Antimicrobial resistance in Pasteurellaceae of veterinary origin. Microbiol Spectr 2018; 6:3 [View Article] [PubMed]
    [Google Scholar]
  11. Bossé JT, Li Y, Rogers J, Fernandez Crespo R, Li Y et al. Whole genome sequencing for surveillance of antimicrobial resistance in Actinobacillus pleuropneumoniae. Front Microbiol 2017; 8:311 [View Article] [PubMed]
    [Google Scholar]
  12. Chiers K, De Waele T, Pasmans F, Ducatelle R, Haesebrouck F. Virulence factors of Actinobacillus pleuropneumoniae involved in colonization, persistence and induction of lesions in its porcine host. Vet Res 2010; 41:65 [View Article] [PubMed]
    [Google Scholar]
  13. Kuban V, Macek P, Hritz J, Nechvatalova K, Nedbalcova K et al. Structural basis of Ca2+-dependent self-processing activity of repeat-in-toxin proteins. mBio 2020; 11:e00226-20 [View Article] [PubMed]
    [Google Scholar]
  14. Loera-Muro A, Angulo C. New trends in innovative vaccine development against Actinobacillus pleuropneumoniae. Vet Microbiol 2018; 217:66–75 [View Article] [PubMed]
    [Google Scholar]
  15. Langford PR, Stringer OW, Li Y, Bossé JT. Application of the MISTEACHING(S) disease susceptibility framework to Actinobacillus pleuropneumoniae to identify research gaps: an exemplar of a veterinary pathogen. Anim Health Res Rev 2021; 22:120–135 [View Article] [PubMed]
    [Google Scholar]
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