1887

Abstract

Carbapenem-resistant (CRKP) is increasingly isolated in paediatric wards, posing a severe threat to these vulnerable populations. This study investigated the clinical features, determinants of carbapenem resistance and clonal relatedness among CRKP in our hospital.

The prevalence of carbapenem-resistant in paediatric patients differs from the strains isolated from adult patients in carbapenemase and predominant clones.

To investigate the pattern of carbapenemase and the clonal relationships between carbapenem-resistant in a paediatric hospital in Jiangxi Province.

Forty-five CRKP isolates were consecutively collected from October 2016 to October 2020. Medical records were reviewed to analyse clinical features. Detection of carbapenemase genes was used to determine CRKP resistance mechanisms and clonal relatedness among CRKP was identified through multi-locus sequence typing (MLST).

Forty-three (95.6 %) patients developed CRKP infection, and two (4.4 %) were colonized by CRKP in the urinary tract. The overall mortality rate was 13.3 %. In total, 42 (93.3 %) strains were positive for carbapenemase genes, and (62.2 %) was the predominant gene. The MLST identified 24 different sequence types (STs) of CRKP, in which ST11 (=8, 17.8 %) and ST2735 (=8, 17.8 %) were the most common STs.

The pattern of CRKP in paediatric patients reflects evolving changes. The ST2735 may present as a dangerous CRKP clone circulating in paediatric patients.

Funding
This study was supported by the:
  • Jiangxi Provincial Department of Science and Technology (Award NO.20195589)
    • Principle Award Recipient: YanZhou
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2022-01-21
2024-10-06
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