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Abstract

Carbapenems are potent members of the β-lactam family that inhibit bacterial cell-wall biosynthesis inhibitors . They are highly effective against Gram-negative and Gram-positive drug-resistant infections . As such, carbapenems are typically reserved as an antibiotic of last resort. The WHO lists meropenem as an essential medicine. Nausea and vomiting are reported in ≤20% of carbapenem recipients, with 1.5% suffering seizures. Enzymatic hydrolysis of the βlactam ring is the main driver of clinical resistance. These enzymes can be classified as Class A, B and D. Classes A and D are serine βlactamases, whereas Class B rely on metal-mediated hydrolysis, typically through zinc.

Funding
This study was supported by the:
  • Wellcome Trust (Award 108876/Z/15/Z)
    • Principle Award Recipient: SamuelJacob Fenn
  • Wellcome Trust (Award 108876/Z/15/Z)
    • Principle Award Recipient: TomArmstrong
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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/content/journal/jmm/10.1099/jmm.0.001462
2021-12-10
2022-01-27
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