1887

Abstract

Colistin is one of the last-resort antibiotics for treating multidrug-resistant (MDR) or extensively drug-resistant (XDR) lactose non-fermenting Gram-negative bacteria such as and .

As the rate of colistin resistance is steadily rising, there is a need for rapid and accurate antimicrobial susceptibility testing methods for colistin. The Rapid ResaPolymyxin / NP test has recently been developed for rapid detection of colistin resistance in and .

The present study aimed to evaluate the performance of the Rapid ResaPolymyxin / NP test in comparison with the reference broth microdilution (BMD) method.

The Rapid ResaPolymyxin / NP test was performed using a total of 135 . (17 colistin-resistant and 118 colistin-susceptible) and 66 isolates (32 colistin-resistant and 34 colistin-susceptible), in comparison with the reference BMD method.

The categorical agreement of the Rapid ResaPolymyxin / NP test with the reference BMD method was 97.5 % with a major error rate of 0 % (0/152) and a very major error (VME) rate of 10.2 %. The VME rate was higher (23.5 %) when calculated separately for isolates. The overall sensitivity and specificity were 89.8 and 100 %, respectively.

The Rapid ResaPolymyxin / NP test performed better for than for .

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2021-06-24
2024-05-10
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