Profile of specific antibodies to the SARS-CoV-2

Danlei Mou; Huahua Feng; Ruiyuan Cao; Xing Weng; Lizhe Zhao; Lingling Yang; Ronghua Jin; Weijun Chen

doi:10.1099/jmm.0.001335

Volume 70, Issue 3

Short Communication

Open Access

Profile of specific antibodies to the SARS-CoV-2

Danlei Mou¹, Huahua Feng², Ruiyuan Cao³, Xing Weng², Lizhe Zhao², Lingling Yang², Ronghua Jin¹ and Weijun Chen^2,4
View Affiliations Hide Affiliations

Affiliations: ¹ Beijing Youan Hospital, Capital Medical University, Beijing, PR China ² BGI PathoGenesis Pharmaceutical Technology, BGI-Shenzhen, Shenzhen, Guangdong, PR China ³ National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, PR China ⁴ BGI Education Center, University of Chinese Academy of Sciences, Beishan Industry Area 11, Shenzhen, PR China
*Correspondence: Ronghua Jin, [email protected] *Correspondence: Weijun Chen, [email protected]
Published: 18 March 2021 https://doi.org/10.1099/jmm.0.001335

Abstract

In this work, we studied the profile of IgM and IgG antibody responses to SARS-CoV-2 in 32 patients with COVID-19 from day 1 to day 24. IgM remained measurable for a much shorter period than IgG, suggesting that IgG antibody may represent the primary immune response.

Received: 04/06/2020
Accepted: 08/02/2021
Published Online: 18/03/2021

Keyword(s): antibodies , SARS-CoV-2 and Spike RBD protein

Funding

This study was supported by the:

National Major Project for Control and Prevention of Infectious Disease in China (Award 2018ZX10301101-004)
- Principle Award Recipient: DanleiMou
National Major Project for Control and Prevention of Infectious Disease in China (Award 2018ZX10732-401)
- Principle Award Recipient: MouDanlei

This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.

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References

Zhu N, Zhang D, Wang W, Li X, Yang B et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; 382:727–733 [View Article][PubMed]
[Google Scholar]
Lu R, Zhao X, Li J, Niu P, Yang B et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020; 395:565–574 [View Article][PubMed]
[Google Scholar]
Li G, Chen X, Xu A. Profile of specific antibodies to the SARS-associated coronavirus. N Engl J Med 2003; 349:508–509 [View Article][PubMed]
[Google Scholar]

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Profile of specific antibodies to the SARS-CoV-2

J. Med. Microbiol. 70, 001335 (2021); https://doi.org/10.1099/jmm.0.001335

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Volume 70, Issue 3

Short Communication

Open Access

Profile of specific antibodies to the SARS-CoV-2

Abstract

Funding

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