1887

Abstract

We describe a longitudinal study carried out in an adult outbreak-associated cohort to investigate health effects, including post-infectious irritable bowel syndrome, occurring after resolution of acute Cryptosporidium parvum infection. New symptoms self-reported up to 12 months included: weight loss (31 %), abdominal pain (38 %), diarrhoea (33 %), eye pain (9 %), joint pain (33 %), fatigue (22 %) and symptoms consistent with irritable bowel syndrome (IBS) (28 %). Two people were medically diagnosed with IBS. This study describes for the first time sequelae reported by patients up to 12 months after infection with C. parvum, which appear to be similar to those described with C. hominis.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.000609
2017-10-06
2019-10-22
Loading full text...

Full text loading...

/deliver/fulltext/jmm/66/11/1607.html?itemId=/content/journal/jmm/10.1099/jmm.0.000609&mimeType=html&fmt=ahah

References

  1. Public Health England Cryptosporidiosis, guidance, data and analysis. 2014
  2. Kotloff KL, Nataro JP, Blackwelder WC, Nasrin D, Farag TH et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. Lancet 2013;382:209–222 [CrossRef][PubMed]
    [Google Scholar]
  3. Hunter PR, Hughes S, Woodhouse S, Raj N, Syed Q et al. Health sequelae of human cryptosporidiosis in immunocompetent patients. Clin Infect Dis 2004;39:504–510 [CrossRef][PubMed]
    [Google Scholar]
  4. Bushen OY, Kohli A, Pinkerton RC, Dupnik K, Newman RD et al. Heavy cryptosporidial infections in children in northeast Brazil: comparison of Cryptosporidium hominis and Cryptosporidium parvum. Trans R Soc Trop Med Hyg 2007;101:378–384 [CrossRef][PubMed]
    [Google Scholar]
  5. Hay EM, Winfield J, McKendrick MW. Reactive arthritis associated with Cryptosporidium enteritis. Br Med J 1987;295:248 [CrossRef][PubMed]
    [Google Scholar]
  6. Ozgül A, Tanyüksel M, Yazicioglu K, Arpacioglu O. Sacroiliitis associated with Cryptosporidium parvum in an HLA-B27-negative patient. Rheumatology 1999;38:288–289 [CrossRef][PubMed]
    [Google Scholar]
  7. Shepherd RC, Smail PJ, Sinha GP. Reactive arthritis complicating cryptosporidial infection. Arch Dis Child 1989;64:743–744 [CrossRef][PubMed]
    [Google Scholar]
  8. Cron RQ, Sherry DD. Reiter's syndrome associated with cryptosporidial gastroenteritis. J Rheumatol 1995;22:1962–1963[PubMed]
    [Google Scholar]
  9. Manthey MW, Ross AB, Soergel KH. Cryptosporidiosis and inflammatory bowel disease. Experience from the Milwaukee outbreak. Dig Dis Sci 1997;42:1580–1586 [CrossRef][PubMed]
    [Google Scholar]
  10. Colussi O, Rouen A, Seksik P, Cosnes J, Beaugerie L et al. Acute cryptosporidiosis as a cause of sudden recurrence of digestive symptoms in patients with Crohn's disease. J Crohns Colitis 2010;4:669–670 [CrossRef][PubMed]
    [Google Scholar]
  11. Vadlamudi N, Maclin J, Dimmitt RA, Thame KA. Cryptosporidial infection in children with inflammatory bowel disease. J Crohns Colitis 2013;7:e337–e343 [CrossRef][PubMed]
    [Google Scholar]
  12. Rehn M, Wallensten A, Widerström M, Lilja M, Grunewald M et al. Post-infection symptoms following two large waterborne outbreaks of Cryptosporidium hominis in Northern Sweden, 2010-2011. BMC Public Health 2015;15:529 [CrossRef][PubMed]
    [Google Scholar]
  13. Guerrant DI, Moore SR, Lima AA, Patrick PD, Schorling JB et al. Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and cognitive function four-seven years later in a poor urban community in northeast Brazil. Am J Trop Med Hyg 1999;61:707–713 [CrossRef][PubMed]
    [Google Scholar]
  14. Agnew DG, Lima AA, Newman RD, Wuhib T, Moore RD et al. Cryptosporidiosis in northeastern Brazilian children: association with increased diarrhea morbidity. J Infect Dis 1998;177:754–760 [CrossRef][PubMed]
    [Google Scholar]
  15. Bartelt LA, Lima AA, Kosek M, Peñataro Yori P, Lee G et al. "Barriers" to child development and human potential: the case for including the "neglected enteric protozoa" (NEP) and other enteropathy-associated pathogens in the NTDs. PLoS Negl Trop Dis 2013;7:e2125 [CrossRef][PubMed]
    [Google Scholar]
  16. Jones J, Boorman J, Cann P, Forbes A, Gomborone J et al. British Society of Gastroenterology guidelines for the management of the irritable bowel syndrome. Gut 2000;47:ii1–ii19 [CrossRef][PubMed]
    [Google Scholar]
  17. Rodríguez LA, Ruigómez A. Increased risk of irritable bowel syndrome after bacterial gastroenteritis: cohort study. BMJ 1999;318:565–566 [CrossRef][PubMed]
    [Google Scholar]
  18. Hanevik K, Dizdar V, Langeland N, Hausken T. Development of functional gastrointestinal disorders after Giardia lamblia infection. BMC Gastroenterol 2009;9:27 [CrossRef][PubMed]
    [Google Scholar]
  19. Marion R, Baishanbo A, Gargala G, François A, Ducrotté P et al. Transient neonatal Cryptosporidium parvum infection triggers long-term jejunal hypersensitivity to distension in immunocompetent rats. Infect Immun 2006;74:4387–4389 [CrossRef][PubMed]
    [Google Scholar]
  20. Khaldi S, Gargala G, Le Goff L, Parey S, Francois A et al. Cryptosporidium parvum isolate-dependent postinfectious jejunal hypersensitivity and mast cell accumulation in an immunocompetent rat model. Infect Immun 2009;77:5163–5169 [CrossRef][PubMed]
    [Google Scholar]
  21. McKerr C, Adak GK, Nichols G, Gorton R, Chalmers RM et al. An outbreak of Cryptosporidium parvum across England & Scotland associated with consumption of fresh pre-cut salad leaves, May 2012. PLoS One 2015;10:e0125955 [CrossRef][PubMed]
    [Google Scholar]
  22. Insulander M, Silverlås C, Lebbad M, Karlsson L, Mattsson JG et al. Molecular epidemiology and clinical manifestations of human cryptosporidiosis in Sweden. Epidemiol Infect 2013;141:1009–1020 [CrossRef][PubMed]
    [Google Scholar]
  23. MacKenzie WR, Schell WL, Blair KA, Addiss DG, Peterson DE et al. Massive outbreak of waterborne Cryptosporidium infection in Milwaukee, Wisconsin: recurrence of illness and risk of secondary transmission. Clin Infect Dis 1995;21:57–62 [CrossRef][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.000609
Loading
/content/journal/jmm/10.1099/jmm.0.000609
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error