1887

Abstract

The reported incidence of Legionnaires' disease caused by has increased since 2008 in Scotland. While microbiological and epidemiological studies have identified exposure to growing media as a risk factor for infection, little is known about the differences regarding disease risk factors, clinical features and outcomes of infection with when compared with A nested case–case study was performed comparing 12 cases with 25 confirmed cases. Fewer infected patients reported being smokers [27 % (95 % CI 2–52 %) vs. 68 % (95 % CI 50–86 %),  = 0.034] but more patients experienced breathlessness [67 % (95 % CI 40–94 %) vs. 28 % (95 % CI 10–46 %),  = 0.036]. Significantly more -infected patients received treatment in intensive care [50 % (95 % CI 22–78 %) vs. 12 % (95 % CI 0–25 %),  = 0.036]. However, the differences in diagnostic methods between the two groups may have led to only the most severe cases of being captured by the surveillance system. No differences were observed in any of the other pre-hospital symptoms assessed. Our results highlight the similarity of Legionnaires' disease caused by and , and reinforce the importance of diagnostic tools other than the urinary antigen assays for the detection of non- species. Unfortunately, cases of community-acquired pneumonia caused by species will continue to be underdiagnosed unless routine testing criteria changes.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.000215
2016-02-01
2020-09-23
Loading full text...

Full text loading...

/deliver/fulltext/jmm/65/2/142.html?itemId=/content/journal/jmm/10.1099/jmm.0.000215&mimeType=html&fmt=ahah

References

  1. Amodeo M. R., Murdoch D. R., Pithie A. D.. 2010; Legionnaires' disease caused by Legionella longbeachae and Legionella pneumophila: comparison of clinical features, host-related risk factors, and outcomes. Clin Microbiol Infect16:1405–1407 [CrossRef][PubMed]
    [Google Scholar]
  2. Burdet C., Lepeule R., Duval X., Caseris M., Rioux C., Lucet J.-C., Yazdanpanah Y.. 2014; Quinolones versus macrolides in the treatment of legionellosis: a systematic review and meta-analysis. J Antimicrob Chemother69:2354–2360 [CrossRef][PubMed]
    [Google Scholar]
  3. Cameron S., Roder D., Walker C., Feldheim J.. 1991; Epidemiological characteristics of Legionella infection in South Australia: implications for disease control. Aust N Z J Med21:65–70 [CrossRef][PubMed]
    [Google Scholar]
  4. Currie S. L., Beattie T. K., Knapp C. W., Lindsay D. S. J.. 2014; Legionella spp. in UK composts–a potential public health issue?. Clin Microbiol Infect20:O224–O229 [CrossRef][PubMed]
    [Google Scholar]
  5. European Centre for Disease Prevention and Control (ECDC) 2012; European Legionnaires' disease surveillance network (ELDSNet): Operating procedure Available: http://ecdc.europa.eu/en/healthtopics/legionnaires_disease/ELDSNet/Pages/index.aspx Accessed: 14th September 2015
    [Google Scholar]
  6. European Centre for Disease Prevention and Control (ECDC) 2014; Legionnaires' disease in Europe 2013 Available: http://ecdc.europa.eu/en/healthtopics/legionnaires_disease/Pages/Publications.aspx. Accessed: 7th October 2015
    [Google Scholar]
  7. Fields B. S., Benson R. F., Besser R. E.. 2002; Legionella and Legionnaires' disease: 25 years of investigation. Clin Microbiol Rev15:506–526 [CrossRef][PubMed]
    [Google Scholar]
  8. Graham F. F., White P. S., Harte D. J. G., Kingham S. P.. 2012; Changing epidemiological trends of legionellosis in New Zealand, 1979-2009. Epidemiol Infect140:1481–1496 [CrossRef][PubMed]
    [Google Scholar]
  9. Health Protection Scotland (HPS) 2014; Cluster of Legionella longbeachae cases in Scotland in September/October 2013 Available: http://www.hps.scot.nhs.uk/resp/publicationsdetail.aspx?id = 58958&subjectid = 185,97. Accessed: 8th October 2015
    [Google Scholar]
  10. Lim W. S., Baudouin S. V., George R. C., Hill A. T., Jamieson C., Le Jeune I., Macfarlane J. T., Read R. C., Roberts H. J., other authors. 2009; BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax64:(Suppl 3)iii1–iii55 [CrossRef][PubMed]
    [Google Scholar]
  11. Murdoch D. R., Podmore R. G., Anderson T. P., Barratt K., Maze M. J., French K. E., Young S. A., Chambers S. T., Werno A. M.. 2013; Impact of routine systematic polymerase chain reaction testing on case finding for Legionnaires' disease: a pre-post comparison study. Clin Infect Dis57:1275–1281 [CrossRef][PubMed]
    [Google Scholar]
  12. O'Connor B. A., Carman J., Eckert K., Tucker G., Givney R., Cameron S.. 2007; Does using potting mix make you sick? Results from a Legionella longbeachae case-control study in South Australia. Epidemiol Infect135:34–39 [CrossRef][PubMed]
    [Google Scholar]
  13. Pedro-Botet L., Yu V. L.. 2006; Legionella: macrolides or quinolones?. Clin Microbiol Infect12:(Suppl 3)25–30 [CrossRef][PubMed]
    [Google Scholar]
  14. Potts A., Donaghy M., Marley M., Othieno R., Stevenson J., Hyland J., Pollock K. G., Lindsay D., Edwards G., other authors. 2013; Cluster of Legionnaires disease cases caused by Legionella longbeachae serogroup 1, Scotland, August to September 2013. Euro Surveill18:20656 [CrossRef][PubMed]
    [Google Scholar]
  15. Pravinkumar S. J., Edwards G., Lindsay D., Redmond S., Stirling J., House R., Kerr J., Anderson E., Breen D., other authors. 2010; A cluster of Legionnaires' disease caused by Legionella longbeachae linked to potting compost in Scotland, 2008-2009. Euro Surveill15:19496[PubMed]
    [Google Scholar]
  16. Public Health England (PHE) 2015; Legionnaires' disease in England and Wales Available: https://www.gov.uk/government/collections/legionnaires-disease-guidance-data-and-analysis#epidemiology. Accessed: 7th October 2015
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.000215
Loading
/content/journal/jmm/10.1099/jmm.0.000215
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error