1887

Abstract

Minocycline (MIN) usually shows good activity against strains. The reintroduction to the market of intravenous MIN provides an additional agent to the limited options for the treatment of infections. The activity of MIN as a single agent and in combination with rifampicin (RIF), colistin (COL) or imipenem (IMI) was evaluated by means of killing curves and 24 h-time-kill curves in five isolates which were selected on the basis of different antimicrobial resistance profiles. MIN showed bacteriostatic activity in three isolates (2 ×  or 16 ×  MIC) and bactericidal activity in the other isolates (64 ×  MIC). In isolates harbouring the gene, the associations studied were always indifferent. However, in isolates not harbouring , the use of MIN in combination showed a rapid synergistic effect (at 4 h) in four out of nine combinations (two with RIF and one each with IMI and COL). At 24 h, this effect was observed in six out of nine combinations (two in each association). MIN in combination with RIF, IMI and COL showed bactericidal synergy in most of the isolates which did not harbour the gene, but the combinations were not synergistic in -positive isolates.

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2015-10-01
2019-11-17
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