1887

Abstract

The prevalence of community-acquired meticillin-resistant (CA-MRSA) strains has become a serious problem worldwide. The aim of this study was to investigate the annual transitions of MRSA strains with the CA-MRSA feature, which were identified as SCC type IV or V, in a hospital setting in Japan. Between 2005 and 2012, MRSA strains were collected from a tertiary-care hospital in Tokyo, Japan, and SCC typing, detection of the virulence factors and antimicrobial susceptibility testing were conducted. The rate of detection of type II SCC, which is found mainly in healthcare-associated MRSA, significantly decreased from 90.0 (2005–2006) to 74.3 % (2011–2012) ( < 0.01). In contrast, the rate of detection of type IV SCC, which is mainly found in CA-MRSA, significantly increased from 5.8 (2005–2006) to 16.3 % (2011–2012) ( < 0.01). The rate of detection of the toxic shock syndrome toxin-1 gene significantly decreased from 66.7 (2005–2006) to 51.6 % (2011–2012) ( < 0.01), whilst that of the Panton-Valentine leukocidin gene significantly increased from 0.1 (2005–2006) to 2.1 % (2011–2012) ( < 0.01). The resistance rates of cefotaxime, levofloxacin, clarithromycin and minocycline decreased every year. The resistance rates of these antimicrobial agents for the SCC type IV or V strains were significantly lower than those for the SCC type I or II strains ( < 0.01, respectively). Therefore, these results suggest that the annual transitions of the virulence factors and antibiograms in MRSA are closely related to the increase of SCC type IV/V strains.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.000080
2015-07-01
2020-01-22
Loading full text...

Full text loading...

/deliver/fulltext/jmm/64/7/745.html?itemId=/content/journal/jmm/10.1099/jmm.0.000080&mimeType=html&fmt=ahah

References

  1. Boye K. , Bartels M.D. , Andersen I.S. , Møller J.A. , Westh H. . ( 2007;). A new multiplex PCR for easy screening of methicillin-resistant Staphylococcus aureus SCCmec types I-V. Clin Microbiol Infect 13: 725–727 [CrossRef] [PubMed].
    [Google Scholar]
  2. Campanile F. , Bongiorno D. , Borbone S. , Stefani S. . ( 2009;). Hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) in Italy. Ann Clin Microbiol Antimicrob 8: 22 [CrossRef] [PubMed].
    [Google Scholar]
  3. Chuang Y.Y. , Huang Y.C. . ( 2013;). Molecular epidemiology of community-associated meticillin-resistant Staphylococcus aureus in Asia. Lancet Infect Dis 13: 698–708 [CrossRef] [PubMed].
    [Google Scholar]
  4. CLSI ( 2009;). Method for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically Approved Standard M07-A8 Wayne, PA: Clinical and Laboratory Standards Institute;.
    [Google Scholar]
  5. DeLeo F.R. , Otto M. , Kreiswirth B.N. , Chambers H.F. . ( 2010;). Community-associated meticillin-resistant Staphylococcus aureus . Lancet 375: 1557–1568 [CrossRef] [PubMed].
    [Google Scholar]
  6. Deresinski S. . ( 2005;). Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey. Clin Infect Dis 40: 562–573 [CrossRef] [PubMed].
    [Google Scholar]
  7. Diekema D.J. , Pfaller M.A. , Schmitz F.J. , Smayevsky J. , Bell J. , Jones R.N. , Beach M. , SENTRY Partcipants Group . ( 2001;). Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis 32: (Suppl 2), S114–S132 [CrossRef] [PubMed].
    [Google Scholar]
  8. International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC) ( 2009;). Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements. Antimicrob Agents Chemother 53: 4961–4967 [CrossRef] [PubMed].
    [Google Scholar]
  9. Isobe H. , Takano T. , Nishiyama A. , Hung W.C. , Kuniyuki S. , Shibuya Y. , Reva I. , Yabe S. , Iwao Y. , other authors . ( 2012;). Evolution and virulence of Panton-Valentine leukocidin-positive ST30 methicillin-resistant Staphylococcus aureus in the past 30 years in Japan. Biomed Res 33: 97–109.[CrossRef]
    [Google Scholar]
  10. Landrum M.L. , Neumann C. , Cook C. , Chukwuma U. , Ellis M.W. , Hospenthal D.R. , Murray C.K. . ( 2012;). Epidemiology of Staphylococcus aureus blood and skin and soft tissue infections in the US military health system, 2005-2010. JAMA 308: 50–59 [CrossRef] [PubMed].
    [Google Scholar]
  11. Li S. , Skov R.L. , Han X. , Larsen A.R. , Larsen J. , Sørum M. , Wulf M. , Voss A. , Hiramatsu K. , Ito T. . ( 2011;). Novel types of staphylococcal cassette chromosome mec elements identified in clonal complex 398 methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother 55: 3046–3050 [CrossRef] [PubMed].
    [Google Scholar]
  12. Nakaminami H. , Noguchi N. , Ikeda M. , Hasui M. , Sato M. , Yamamoto S. , Yoshida T. , Asano T. , Senoue M. , Sasatsu M. . ( 2008;). Molecular epidemiology and antimicrobial susceptibilities of 273 exfoliative toxin-encoding-gene-positive Staphylococcus aureus isolates from patients with impetigo in Japan. J Med Microbiol 57: 1251–1258 [CrossRef] [PubMed].
    [Google Scholar]
  13. Nakaminami H. , Noguchi N. , Ito A. , Ikeda M. , Utsumi K. , Maruyama H. , Sakamoto H. , Senoo M. , Takasato Y. , Nishinarita S. . ( 2014;). Characterization of methicillin-resistant Staphylococcus aureus isolated from tertiary care hospitals in Tokyo, Japan. J Infect Chemother 20: 512–515 [CrossRef] [PubMed].
    [Google Scholar]
  14. Nichol K.A. , Adam H.J. , Hussain Z. , Mulvey M.R. , McCracken M. , Mataseje L.F. , Thompson K. , Kost S. , Lagacé-Wiens P.R. , other authors . ( 2011;). Comparison of community-associated and health care-associated methicillin-resistant Staphylococcus aureus in Canada: results of the CANWARD 2007-2009 study. Diagn Microbiol Infect Dis 69: 320–325 [CrossRef] [PubMed].
    [Google Scholar]
  15. Niki Y. , Matsumoto T. , Yagisawa M. , Kohno S. , Aoki N. , Watanabe A. , Sato J. , Hattori R. , Koashi N. , other authors . ( 2011;). Nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy in 2008: general view of the pathogens' antibacterial susceptibility. J Infect Chemother 17: 510–523 [CrossRef] [PubMed].
    [Google Scholar]
  16. Noguchi N. , Nakaminami H. , Nishijima S. , Kurokawa I. , So H. , Sasatsu M. . ( 2006;). Antimicrobial agent of susceptibilities and antiseptic resistance gene distribution among methicillin-resistant Staphylococcus aureus isolates from patients with impetigo and staphylococcal scalded skin syndrome. J Clin Microbiol 44: 2119–2125 [CrossRef] [PubMed].
    [Google Scholar]
  17. Shore A.C. , Deasy E.C. , Slickers P. , Brennan G. , O'Connell B. , Monecke S. , Ehricht R. , Coleman D.C. . ( 2011;). Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA mecI mecR1 blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 55: 3765–3773 [CrossRef] [PubMed].
    [Google Scholar]
  18. Takano T. , Higuchi W. , Yamamoto T. . ( 2009;). Superior in vitro activity of carbapenems over anti-methicillin-resistant Staphylococcus aureus (MRSA) and some related antimicrobial agents for community-acquired MRSA but not for hospital-acquired MRSA. J Infect Chemother 15: 54–57 [CrossRef] [PubMed].
    [Google Scholar]
  19. Takata T. , Miyazaki M. , Tanaka K. , Tamura K. , Takata T. , Miyazaki M. , Tanaka K. , Hara S. , Kamimura H. , other authors . ( 2012;). Methicillin-resistant Staphylococcus aureus bloodstream infections in a Japanese University Hospital between 1987 and 2004. J Infect Chemother 18: 199–206 [CrossRef] [PubMed].
    [Google Scholar]
  20. Tristan A. , Bes M. , Meugnier H. , Lina G. , Bozdogan B. , Courvalin P. , Reverdy M.E. , Enright M.C. , Vandenesch F. , Etienne J. . ( 2007;). Global distribution of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, 2006. Emerg Infect Dis 13: 594–600 [CrossRef] [PubMed].
    [Google Scholar]
  21. Vandenesch F. , Naimi T. , Enright M.C. , Lina G. , Nimmo G.R. , Heffernan H. , Liassine N. , Bes M. , Greenland T. , other authors . ( 2003;). Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis 9: 978–984.[CrossRef]
    [Google Scholar]
  22. Zetola N. , Francis J.S. , Nuermberger E.L. , Bishai W.R. . ( 2005;). Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis 5: 275–286 [CrossRef] [PubMed].
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.000080
Loading
/content/journal/jmm/10.1099/jmm.0.000080
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error