1887

Abstract

Summary

The occurrence of yeasts and antibodies to yeasts was studied in patients undergoing open-heart surgery without antifungal prophylaxis, and in a similar group receiving antifungal prophylaxis. An association was demonstrated between the occurrence of commensal yeasts and the appearance of antibodies. None of the patients developed overt systemic or superficial yeast infection. The antigenic stimulus for the post-operative production of antibodies appeared to be the increase in the yeast flora that occurred shortly after operation. When the commensal yeast population was suppressed by antifungal antibiotics, the antibody response was also reduced. The implications of these findings in the interpretation of serological tests for diagnosis of systemic yeast infections are discussed.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-9-3-303
1976-08-01
2021-10-21
Loading full text...

Full text loading...

/deliver/fulltext/jmm/9/3/medmicro-9-3-303.html?itemId=/content/journal/jmm/10.1099/00222615-9-3-303&mimeType=html&fmt=ahah

References

  1. Ellis C. A., Spivack M. L. 1967; The significance of candidaemia. Ann intern Med. 67:511
    [Google Scholar]
  2. Evans E. G. V. 1975; The incidence of pathogenic yeasts among open-heart surgery patients—the value of prophylaxis. J thorac cardiovasc Surg. 70:466
    [Google Scholar]
  3. Evans E. G. V., Richardson M. D., Odds F. C., Holland K. T. 1973; Relevance of antigenicity of Candida albicans growth phases to diagnosis of systemic candidiasis. Br med J. 4:86
    [Google Scholar]
  4. Kozinn P. J., Taschdjian C. L., Seelig M. S., Caroline L., Teitler A. 1969; Diagnosis and therapy of systemic candidiasis. Sabouraudia. 7:98
    [Google Scholar]
  5. Krause W., Matheis H., Wulf K. 1969; Fungaemia and funguria after oral administration of Candida albicans. Lancet. 1:598
    [Google Scholar]
  6. Lodder J. 1970 The yeasts. A taxonomic study. , 2nd ed. Amsterdam;
    [Google Scholar]
  7. Murray I. G., Buckley H. R., Turner G. C. 1969; Serological evidence of Candida infection after open-heart surgery. J med Microbiol. 2:463
    [Google Scholar]
  8. Parsons E. R., Nassau E. 1974; Candida serology in open-heart surgery. J med Microbiol. 7:415
    [Google Scholar]
  9. Seelig M. S., Speth C. P., Kozinn P. J., Toni E. F., Taschdjian C. L. 1973; Candida endocarditis after cardiac surgery—clues to earlier detection. J thorac cardiovasc Surg. 65:583
    [Google Scholar]
  10. Stone H. H., Geheber C. E., Kolb L. D., Kitchens W. R. 1973; Alimentary tract colonization by Candida albicans. J surg Res. 14:273
    [Google Scholar]
  11. Stone H. H., Kolb L. D., Currie C. A., Geheber C. E., Cuzzell J. Z. 1974; Candida sepsis: pathogenesis and principles of treatment. Ann Surg. 179:697
    [Google Scholar]
  12. Taschdjian C. L., Kozinn P. J., Fink H., Cuesta M. B., Caroline L., Kantrowitz A. B. 1969; Post mortem studies of systemic candidiasis. I. Diagnostic validity of precipitin reaction and probable origin of sensitization to cytoplasmic candidal antigens. Sabouraudia. 7:110
    [Google Scholar]
  13. Winner H. I. 1955; A study of Candida albicans agglutinins in human sera. J Hyg Camb. 53:509
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-9-3-303
Loading
/content/journal/jmm/10.1099/00222615-9-3-303
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error