1887

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Volume 9, Issue 1

Immunological heterogeneity among the massociated protein antigens of group-A streptococci Free

Abstract

Summary

Different serotypes of group-A streptococci share common antigens that are closely associated with the type-specific determinant of M protein. By the use of selected human sera containing antibody to these M-associated antigens, we have shown that group-A streptococci can be divided into three categories. The majority of the opacity-factor-negative respiratory serotypes possess a shared M-associated antigen or antigens, to which high titres of antibody are common in patients with rheumatic fever, or patients recovering from upper respiratory infections with certain opacity-factor-negative serotypes. The antibody in these sera has a demonstrable but limited affinity for the M-associated antigens of strains belonging to a second category of M types, the majority of which are opacity-factor-positive serotypes of “throat” or “skin” origin. A third group, consisting mainly of opacity-factor-negative pyoderma serotypes, gave variable results and seemed to be intermediate between the other two categories. Complement-fixation-inhibition tests and absorption studies showed a marked degree of cross-reactivity between the M-associated antigens of the three categories.

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© The Pathological Society of Great Britain and Ireland, 1976
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1976-02-01
2024-04-26
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Immunological heterogeneity among the massociated protein antigens of group-A streptococci
J. Med. Microbiol. 9, 73 (1976); https://doi.org/10.1099/00222615-9-1-73
/content/journal/jmm/10.1099/00222615-9-1-73
/content/journal/jmm/10.1099/00222615-9-1-73
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