1887

Abstract

SUMMARY

The activity of kanamycin, aminosidin, BB-K8, sisomicin, gentamicin and tobramycin, has been compared against a variety of Gram-negative micro-organisms isolated from hospital patients. Clear differences in activity against were observed between these antibiotics, tobramycin, BB-K8 and sisomicin being more active than the others. No major broadening of the spectrum occurred when carbenicillin and cephalothin were combined with the more active aminoglycosides, tobramycin, sisomicin and BB-K8. Synergism was observed against more than 50% of the strains of when BB-K8, tobramycin, sisomicin or gentamicin were combined with carbenicillin and against more than 50% of klebsiella strains when aminosidin, kanamycin or gentamicin were combined with cephalothin.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-7-4-465
1974-11-01
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/jmm/7/4/medmicro-7-4-465.html?itemId=/content/journal/jmm/10.1099/00222615-7-4-465&mimeType=html&fmt=ahah

References

  1. Harwick H. J., Kalmanson G. M., Guze L. B. 1973; In vitro activity of ampicillin or vancomycin combined with gentamicin or streptomycin against enterococci. Anti-microb. Agents Chemother 4:383
    [Google Scholar]
  2. Jackson G. G., Riff L. J. 1971; Pseudomonas bacteremia: pharmacologic and other bases for failure of treatment with gentamicin. J. infect. Dis 124S:185
    [Google Scholar]
  3. Klastersky J., Cappel R., Daneau D. 1972; Clinical significance of in vitro synergism between antibiotics in Gram-negative infections. Antimicrob. Agents Chemother 2:470
    [Google Scholar]
  4. Klastersky J., Henri A., Hensgens C., Vandenborre L., Daneau D. 1973a; Antipseudomonal drugs: comparative study of gentamicin, sisomicin and tobramycin in vitro and in human volunteers. Europ. J. Cancer 9:641
    [Google Scholar]
  5. Klastersky J., Henri A., Vandenborre L. 1973b; Antimicrobial activity of tobramycin and gentamicin used in combination with cephalothin and carbenicillin. Am. J. med. Sci 266:13
    [Google Scholar]
  6. Klastersky J., Swings G., Daneau D. 1970; Antimicrobial activity of the carbeni-cillin/gentamicin combination against Gram-negative bacilli. Am. J. med. Sci 260:373
    [Google Scholar]
  7. McCabe W. R., Jackson G. G. 1965; Treatment of pyelonephritis. Bacterial, drug and host factors in success or failure among 252 patients. New Engl. J. Med 272:1037
    [Google Scholar]
  8. Moellering R. C. Jr, Wennersten C., Weinberg A. N. 1971; Studies on antibiotic synergism against enterococci. I. Bacteriologic studies. J. Lab. clin. Med 77:821
    [Google Scholar]
  9. Schimpff S., Satterlee W., Young V. M., Serpick A. 1971; Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia. New Engl. J. Med 284:1061
    [Google Scholar]
  10. Steers E., Foltz E. L., Graves B. S., Riden J. 1959; Inocula-replicating apparatus for routine testing of bacterial susceptibility to antibiotics. Antibiotics Chemother 9:307
    [Google Scholar]
  11. Tattersall M. H. N., Spiers A. D. S., Darrell J. H. 1972; Initial therapy with combination of five antibiotics in febrile patients with leukaemia and neutropenia. Lancet 1:162
    [Google Scholar]
  12. Waitz J. A., Moss E. L., Drube C. G., Weinstein M. J. 1972; Comparative activity of sisomicin, gentamicin, kanamycin and tobramycin. Antimicrob. Agents Chemother 2:431
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-7-4-465
Loading
/content/journal/jmm/10.1099/00222615-7-4-465
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error