The activity of kanamycin, aminosidin, BB-K8, sisomicin, gentamicin and tobramycin, has been compared against a variety of Gram-negative micro-organisms isolated from hospital patients. Clear differences in activity against were observed between these antibiotics, tobramycin, BB-K8 and sisomicin being more active than the others. No major broadening of the spectrum occurred when carbenicillin and cephalothin were combined with the more active aminoglycosides, tobramycin, sisomicin and BB-K8. Synergism was observed against more than 50% of the strains of when BB-K8, tobramycin, sisomicin or gentamicin were combined with carbenicillin and against more than 50% of klebsiella strains when aminosidin, kanamycin or gentamicin were combined with cephalothin.


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