The MIC of carbenicillin for 111 strains of isolated from the sputum of patients with chronic respiratory infections was estimated. For 72 strains it corresponded to that reported for strains isolated from nonrespiratory sites (25−> 100 g per ml), but for 39 strains it ranged from 6 g per ml to <0.7 g per ml.

About half of the strains were typed serologically, by bacteriophages and by pyocine production. No evidence for cross-infection between the patients was found, nor was there any correlation between sensitivity to carbenicillin and any particular type of organism.

There was no evidence that strains with an abnormally low MIC were more virulent in the respiratory tract than were strains with an “ordinary” MIC; nor did it appear that coexistence with enterobacteria in the respiratory tract affected the carbenicillin resistance of .


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  1. Burns M. W., May J. R. 1968; Bacterial precipitins in serum of patients with cystic fibrosis. Lancet 1:270
    [Google Scholar]
  2. Brumfitt W., Percival A., Leigh D. A. 1967; Clinical and laboratory studies with carbenicillin. A new penicillin active against Pseudomonaspyocyanea . Lancet 1:1289
    [Google Scholar]
  3. Jones R. J., Lowbury E. J. L. 1967; Prophylaxis and therapy for Pseudomonas aeruginosa infection with carbenicillin and with gentamicin. Br. Med. J 3:79
    [Google Scholar]
  4. Knudsen E. T., Rolinson G. N., Sutherland R. 1967; Carbenicillin: a new semisynthetic penicillin active against Pseudomonas pyocyanea . Br. Med. J 3:75
    [Google Scholar]
  5. Noble W. C. 1972; Loss of antibiotic resistance in staphylococci from a skin hospital. Lancet 1:929
    [Google Scholar]

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