1887

Abstract

SUMMARY

Gram-negative bacteria, harbouring R factors that confer resistance to sulphonamides, mutate to trimethoprim resistance at an appreciable rate and are then able to grow in the presence of both trimethoprim and a sulphonamide.

All trimethoprim-resistant organisms isolated in this study were thymine requiring, and it is suggested that the frequency of isolation of organisms resistant to trimethoprim, or combinations of trimethoprim and a sulphonamide, may be increased if adequate thymine or thymidine is included in the media used for their isolation.

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/content/journal/jmm/10.1099/00222615-6-1-13
1973-02-01
2022-01-18
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