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1887

Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 5, Issue 1

Rifampicin In Experimental Infection No Access

Abstract

Summary

The in-vitro sensitivity of 32 strains of to rifampicin was found to be similar to that of . tuberculosis. A 1-mth course of rifampicin in three different dosage regimens was used to treat experimental infection of mouse foot-pads starting 2 and 5 wk after infection. Each regimen led to clinical improvement, but the disease relapsed 6–8 wk after completion of therapy. Treatment of severe lesions for 10 wk produced apparent cure. A 1-mth course of sulphadoxine plus pyrimethamine or of clofazimine proved ineffective, and combination of these with rifampicin were no more effective than rifampicin alone.

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  • Accepted:
  • Published Online:
© J. MED. MICROBIOL. 1972
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/content/journal/jmm/10.1099/00222615-5-1-39
1972-02-01
2025-03-20
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References

  1. Cruickshank R., Stewart Sheila M. 1961; Detection of resistance to Streptomycin, P.A.S. and Isoniazid in tubercle bacilli. Assoc. Clin. Path. Broadsheet no. 32 (new series). London
     [Google Scholar]
  2. Leach R. H., Fenner F. 1954; Studies of Mycobacterium ulcerarts and Mycobacterium balnei. III. Growth in semi-synthetic culture media of Dubos and drug sensitivity in vitro and in vivo. Austral. J. Exp. Biol. Med. Sci. 32:835
     [Google Scholar]
  3. Lunn H. F., Rees R. J. W. 1964; Treatment of mycobacterial skin ulcers in Uganda with a riminophenazine derivative (B.663). Lancet 1:247
     [Google Scholar]
  4. MacCallum P., Tolhurst Jean C., Buckle G., Sissons H. A. 1948; A new mycobacterial infection in man. J. Path. Bact. 60:93
     [Google Scholar]
  5. Pattyn S. R., Royackers J. 1965; Traitement de l’infection expérimentale de la souris par Mycobacterium ulcerans et Mycobacterium balnei.. Annls Soc. beige Med. trop. 45:31
     [Google Scholar]
  6. Uganda Buruli Group. 1970; Clinical features and treatment of pre-ulcerative Buruli lesions (Mycobacterium ulcerans infection). Br. Med. J. 2:390
     [Google Scholar]
/content/journal/jmm/10.1099/00222615-5-1-39
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Rifampicin In Experimental Mycobacterium Ulcerans Infection
J. Med. Microbiol. 5, 39 (1972); https://doi.org/10.1099/00222615-5-1-39
/content/journal/jmm/10.1099/00222615-5-1-39
/content/journal/jmm/10.1099/00222615-5-1-39
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