1887

Abstract

Summary

Two monoclonal antibodies (MAbs) to a 36-kDa extracellular metalloprotease (PSCP) from were found to react with thermolysin, elastase, alkaline protease (Apr) and LasA, protease (SMP), protease (AhP), and both the lethal factor (LF) and protective antigen (PA) of on immunoblots. The MAbs were capable of neutralising the proteolytic activity of thermolysin, elastase and PSCP but not that of Apr, SMP, and AhP. These results suggest that these MAbs may be able to differentiate between the thermolysin and serralysin family of metalloproteases on the basis of their neutralisation capability and could, therefore, be useful tools in the characterisation of new bacterial proteases.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-45-3-219
1996-09-01
2019-11-21
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-45-3-219
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error