1887

Abstract

Summary

The role of exo-enzymes was evaluated in a murine model of endogenous bacteraemia in which the bacteria invaded the bloodstream after oral dosing. Although an elastase mutant PAO-E64 was as virulent as its parent strain PAO l, an exo-enzyme S-deficient mutant, DG1-ExS5 and alkaline protease mutants PAKS-16, PAKS-17, PAKS-19, were less virulent than their parent strains, DG1 and PAKS-1. respectively (p < 0·01). Thus exo-enzyme S and alkaline protease, but not elastase, appear to contribute to the pathogenicity of in this model.

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/content/journal/jmm/10.1099/00222615-43-4-258
1995-10-01
2019-11-14
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-43-4-258
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