Urinary isolates of cysteine-requiring were found to be generally lacking in virulence factors commonly associated with uropathogenic strains. The proportion of auxotrophic strains showing type-1 fimbriation, haemolysin production, motility and sensitivity to normal human serum was significantly less than that of a comparable number of urinary isolates of prototrophic , although the proportion in both groups possessing K1 antigen was similar. Furthermore, the biotyping and serogrouping of these and other strains from systemic infections demonstrated a high degree of phenotypic diversity. This is further evidence that infection with these auxotrophs results from a combination of decreased host resistance and a physiological condition conducive to the random selection of these auxotrophs .


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