1887

Abstract

Summary

Genetically resistant A/J and CBA mice were inoculated intraperitoneally with either 10 or 10 organisms of a virulent strain of ; susceptible C57BL/6J and BALB/c mice were inoculated with either 10 or 10 organisms. Except with the smaller dose in resistant mice, fatal infection ensued. Bacteraemia occurred within 1 h after inoculation, except that it was not detectable during the first 6 h in the susceptible mice inoculated with 10 organisms. From day 2, the circulating bacterial population continued to increase in all infected mice, except that it remained under control in the resistant mice inoculated with the lower dose (10 organisms). The pathogen proliferated logarithmically in the liver from day 2, and a bacterial count of 10 cfu/g of tissue was reached when the animals died at 5–7 days; again, the resistant mice inoculated with 10 organisms were an exception in which the hepatic bacterial population was kept under control and the mice survived.

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1992-06-01
2022-05-28
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References

  1. Plant J., Glynn A. A. Genetics of resistance to infection with Salmonella ivphimurium in mice. J Infect Dis 1976; 133:72–78
    [Google Scholar]
  2. Lissner C. R., Swanson R. N., O’Brien A. D. Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro. J Immunol 1983; 131:3006–3013
    [Google Scholar]
  3. Lissner C. R., Weinstein D. L., O’Brien A. D. Mouse chromosome I Ity locus regulates microbicidal activity of isolated peritoneal macrophages against a diverse group of intracellular and extracellular bacteria. J Immunol 1985; 135:544–547
    [Google Scholar]
  4. Hsu H. S. Pathogenesis and immunity in murine salmonellosis. Microbiol Rev 1989; 53:390–409
    [Google Scholar]
  5. Hsu H. S., Radcliffe A. S. Interactions between macrophages of guinea pigs and salmonellae. I. Fate of Salmonella typhimurium within macrophages of normal guinea pigs. J Bacteriol 1968; 96:191–197
    [Google Scholar]
  6. Plant J., Glynn A. A. Locating salmonella resistance gene on mouse chromosome 1. Clin Exp Immunol 1919; 37:1–6
    [Google Scholar]
  7. Hormaeche C. E. Natural resistance to Salmonella typhimurium in different inbred mouse strains. Immunology 1979; 37:311–318
    [Google Scholar]
  8. O’Brien A. D., Taylor B. A., Rosenstreich D. L. Genetic control of natural resistance to Salmonella typhimurium in mice during the late phase of infection. J Immunol 1984; 133:3313–3318
    [Google Scholar]
  9. Benjamin W. H., Hall P., Roberts S. J., Briles D. E. The primary effect of the Ity locus is on the rate of growth of Salmonella typhimurium that are relatively protected from killing. J Immunol 1990; 144:3143–3151
    [Google Scholar]
  10. Nakoneczna I., Hsu H. S. The comparative histopathology of primary and secondary lesions in murine salmonellosis. Br J Exp Pathol 1980; 61:76–84
    [Google Scholar]
  11. Nakoneczna I., Hsu H. S. Histopathological study of protective immunity against murine salmonellosis induced by killed vaccine. Infect Immun 1983; 39:423–430
    [Google Scholar]
  12. Ding H. F., Nakoneczna I., Hsu H. S. Protective immunity induced in mice by detoxified salmonella lipopolysaccharide. J Med Microbiol 1990; 31:95–102
    [Google Scholar]
  13. Hormaeche C. E. Dead salmonellae or their endotoxin accelerate the early course of a Salmonella infection in mice. Microb Pathogen 1990; 9:213–218
    [Google Scholar]
  14. Hormaeche C. E. The in-vivo division and death rates of Salmonella typhimurium in the spleens of naturally resistant and susceptible mice measured by the superinfecting phage technique of Meynell. Immunology 1980; 41:973–979
    [Google Scholar]
  15. Swanson R. N., O’Brien A. D. Genetic control of the innate resistance of mice to Salmonella typhimurium: Ity gene is expressed in vivo by 24 hours after infection. J Immunol 1983; 131:3014–3020
    [Google Scholar]
  16. Lin F. R., Wang X. M., Hsu H. S., Mumaw V. R., Nakoneczna I. Electron microscopic studies on the location of bacterial proliferation in the liver in murine salmonellosis. Br J Exp Pathol 1987; 68:539–550
    [Google Scholar]
  17. Wang X. M., Lin F. R., Hsu H. S., Mumaw V. R., Nakoneczna I. Electronmicroscopic studies on the location of salmonella proliferation in the murine spleen. J Med Microbiol 1988; 25:41–47
    [Google Scholar]
  18. Lin F. R., Hsu H. S., Mumaw V. R. Nakoneczna., I. Intracellular destruction of salmonellae in genetically resistant mice. J Med Microbiol 1989; 30:79–87
    [Google Scholar]
  19. Lin F. R., Hsu H. S., Mumaw V. R., Moncure C.W. Confirmation of destruction of salmonellae within murine peritoneal exudate cells by immunocytochemical technique. Immunology 1989; 67:394–400
    [Google Scholar]
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