1887

Abstract

Summary

The clinical and diagnostic findings in 20 cases of toxoplasmosis associated with the Acquired Immune Deficiency Syndrome (AIDS) were investigated in a prospective study of patients in south-east England. Individual details were recorded by a standardised questionnaire incorporating an evaluation of initial presentation, radiological findings, therapy and clinical progression. Toxoplasma serology was performed by reference assays and the presence of the parasite in tissue was sought by culture, histological examination and specific DNA detection. Clinical findings at presentation and results of radiological investigation were comparable with previously published experience from the USA. In contrast, sampling of the cerebrospinal fluid was rarely performed and was found to be of little clinical value. Examination of tissue samples was diagnostic when available, but was not performed routinely. Sulphonamide plus pyrimethamine was the treatment of choice in most cases and response to therapy was satisfactory, although a high incidence of toxicity was recorded.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-35-1-1
1991-07-01
2022-01-23
Loading full text...

Full text loading...

/deliver/fulltext/jmm/35/1/medmicro-35-1-1.html?itemId=/content/journal/jmm/10.1099/00222615-35-1-1&mimeType=html&fmt=ahah

References

  1. Ruskin J, Remington JS. Toxoplasmosis in the compromised host. Ann Intern Med 1976; 84:193–199
    [Google Scholar]
  2. Carter AO, Frank JW. Congenital toxoplasmosis: epidemiologic features and control. Can Med Assoc J 1986; 135:618–623
    [Google Scholar]
  3. Wreghitt TG, Hakim M, Gray JJ. et al. Toxoplasmosis in heart and heart and lung transplant recipients. J Clin Pathol 1989; 42:194–199
    [Google Scholar]
  4. Luft BJ, Remington JS. Toxoplasmic encephalitis. J Infect Dis 1988; 157:1–6
    [Google Scholar]
  5. Gransden WR, Brown PM. Pneumocystic pneumonia and disseminated toxoplasmosis in a male homosexual. Br Med J 1983; 286:1614
    [Google Scholar]
  6. Sabin AB, Feldman HA. Dyes as microchemical indicators of a new immunity phenomenon affecting a protozoon parasite (Toxoplasma). Science 1948; 108:660–663
    [Google Scholar]
  7. Holliman RE, Johnson J, Duffy K, New L. Discrepant toxoplasma latex agglutination test results. J Clin Pathol 1989; 42:200–203
    [Google Scholar]
  8. Payne RA, Joynson DHM, Balfour AH. et al. Public Health Laboratory Service enzyme linked immunosorbent assay for detecting Toxoplasma specific IgM antibody. J Clin Pathol 1987; 40:276–281
    [Google Scholar]
  9. Duffy KT, Wharton PJ, Johnson JD, New L, Holliman RE. Assessment of an immunoglobulin-M immunosorbent agglutination assay (ISAGA) for detecting toxoplasma specific IgM. J Clin Pathol 1989; 42:1291–1295
    [Google Scholar]
  10. Savva D, Morris JC, Johnson JD, Holliman RE. Polymerase chain reaction for detection of Toxoplasma gondii. J Med Microbiol 1990; 32:25–31
    [Google Scholar]
  11. Hughes HPA, Hudson L, Fleck DG. In vitro culture of Toxoplasma gondii m primary and established cell lines. Int J Parasitol 1986; 16:317–322
    [Google Scholar]
  12. Holliman RE. Toxoplasmosis and the acquired immune deficiency syndrome. J Infect 1988; 16:121–128
    [Google Scholar]
  13. Naot Y, Luft BJ, Remington JS. False-positive serological tests in heart transplant recipients. Lancet 1981; 2:590–591
    [Google Scholar]
  14. The TE Study Group Haverkos HW. Assessment of therapy for toxoplasma encephalitis. Am J Med 1987; 82:907–914
    [Google Scholar]
  15. Elkin CM, Leon E, Grenell SL, Leeds NE. Intracranial lesions in the acquired immunodeficiency syndrome. JAMA 1985; 253:393–396
    [Google Scholar]
  16. Potsman I, Resnick L, Luft BJ, Remington JS. Intrathecal production of antibodies against Toxoplasma gondii in patients with toxoplasmic encephalitis and the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 1988; 108:49–51
    [Google Scholar]
  17. Navia BA, Petito CK, Gold JW, Cho ES, Jordan BD, Price RW. Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: clinical and neuropathological findings in 27 patients. Ann Neurol 1986; 19:224–238
    [Google Scholar]
  18. Holliman RE, Johnson JD. The post-natal serodiagnosis of congenital toxoplasmosis. Serodiag Immunother 1989; 3:323–327
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-35-1-1
Loading
/content/journal/jmm/10.1099/00222615-35-1-1
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error