1887

Abstract

Surmmary

Unlike their parent strains, zidovudine-resistant derivatives of KL16 and NCTC 5710 were found to be incapable of incorporating radiolabeled thymidine into their chromosomal DNA. Since incorporation was still prevented in the presence of EDTA, resistance to zidovudine was not associated with a permeability barrier, but appeared to result from the loss of thymidine kinase activity, required for the phosphorylation of zidovudine. , which is intrinsically zidovudine-resistant, was also shown to be incapable of incorporating thymidine into its DNA, but SK360 and E3T, which are also intrinsically zidovudine-resistant, possessed thymidine kinase activity. This suggests that two distinct mechanisms of resistance to zidovudine exist in bacteria. Zidovudine resistance did not appear to confer resistance to other antibacterial agents.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-33-4-235
1990-12-01
2019-10-20
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-33-4-235
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error