Antisera to two antigens of —plasma membrane (PM) protein and an affinity-purified surface antigen (SA56)—were raised in rabbits, and shown to agglutinate and kill trophozoites . These antibodies were also demonstrated by ELISA in the sera of paediatric patients with giardiasis. The titres of both antibodies were significantly higher in non-persistent (acute) and asymptomatic cases than in patients with persistent infection; and the latter group did not respond to anti-giardial therapy. The inability of this group to clear infection, in spite of therapy, may result from the low level of antibodies which mediate the killing of trophozoites.


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